Clinical Study
Evaluation of Acute Locoregional Toxicity in Patients with Breast Cancer Treated with Adjuvant Radiotherapy in Combination with Pazopanib
Table 2
Acute locoregional toxicity of concurrent Pazopanib + RT versus RT alone scored using CTCAE.
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Locoregional toxicity | Pazopanib + RT | RT Alone | Grade 1-2 | Grade 3–5 | Grade 1-2 | Grade 3–5 | n affected (total) | n affected (total) | n affected (total) | n affected (total) |
| Fatigue | 12 (12) | 0 (12) | 25 (25) | 0 (25) | Dermatitis radiation | 12 (12) | 0 (12) | 21 (19) | 4 (25) | Skin hyperpigmentation | 2 (12) | 0 (12) | 15 (25) | 0 (25) | Skin ulceration | 1 (12) | 0 (12) | 0 (25) | 0 (25) | Soft tissue fibrosis | 0 (12) | 0 (12) | 0 (25) | 0 (25) | Pneumonitis | 0 (12) | 0 (12) | 0 (25) | 0 (25) | Diarrhea | 3 (12) | 0 (12) | 0 (25) | 0 (25) | Hypertension | 1 (12) | 0 (12) | 0 (25) | 0 (25) | Nausea | 2 (12) | 0 (12) | 0 (25) | 0 (25) | Anorexia | 1 (12) | 1 (12) | 0 (25) | 0 (25) |
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RT: radiotherapy; CTCAE: Common Terminology Criteria for Adverse Events (v4.0).
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