Inappropriate Use of Gastric Acid Suppression Therapy in Hospitalized Patients with Clostridium difficile—Associated Diarrhea: A Ten-Year Retrospective Analysis
Table 1
ASHP therapeutic guidelines on stress ulcer prophylaxis [7].
Intensive care unit (ICU) patient plus one of the following:
(1) Coagulopathy (i.e., platelet count of <50,000 mm3, international normalized ratio (INR) >1.5, or an activated partial thromboplastin time (aPTT) >2 times control)
(2) Mechanical ventilation for >48 hours
(3) History of gastrointestinal ulceration or bleeding within one year of admission
(4) Glasgow coma score of ≤10
(5) Thermal injury to >35% of body surface area
(6) Partial hepatectomy
(7) Multiple trauma (injury severity score of ≥16)
(8) Transplantation perioperatively in the ICU
(9) Spinal cord injury
(10) Hepatic failure
(11) Two or more of the following risk factors: sepsis, ICU stay of greater than one week, occult bleeding lasting at least six days, and high-dose corticosteroids (>250 mg/day of hydrocortisone)
