Senescence-Accelerated Mice P8: A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model

Table 2

Histopathological and cellular markers of AD and aging found in SAMP8.

Target	Modification	References
Tau protein	Increased levels and phosphorylation	[22, 55, 56]
Tau kinases	Increased levels or activity in Cdk5/p25 and GSK3𝛽	[22, 58, 59]
Receptor for advanced glycation end product (RAGE)	Increased	[75]
APP protein	Increased	[63–65, 80, 85, 86]
B-amyloid	Amyloid content increased and aggregates	[26, 61, 62, 69, 70, 74, 87]
Secretases	ADAM-10 and PS1	[65, 80, 88]
BBH	Disrupted	[72, 73, 89]