Table of Contents
ISRN Pulmonology
Volume 2012 (2012), Article ID 926345, 5 pages
http://dx.doi.org/10.5402/2012/926345
Research Article

A Model Simulation for Decreased Left Ventricular Stroke Volume in Obstructive Sleep-Disordered Breathing

Department of Anesthesiology, Wexner Medical Center at The Ohio State University, 410 W. 10th Avenue, Columbus, OH 43210, USA

Received 18 August 2012; Accepted 27 September 2012

Academic Editors: P. Von Wichert and C. C. Witt

Copyright © 2012 Ernesto Goldman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Alchanatis, G. Tourkohoriti, E. N. Kosmas et al., “Evidence for left ventricular dysfunction in patients with obstructive sleep apnoea syndrome,” European Respiratory Journal, vol. 20, no. 5, pp. 1239–1245, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. T. D. Bradley and J. S. Floras, “Obstructive sleep apnoea and its cardiovascular consequences,” The Lancet, vol. 373, no. 9657, pp. 82–93, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. T. D. Bradley, M. J. Hall, S. I. Ando, and J. S. Floras, “Hemodynamic effects of simulated obstructive apneas in humans with and without heart failure,” Chest, vol. 119, no. 6, pp. 1827–1835, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. A. J. Buda, M. R. Pinsky, and N. B. Ingels, “Effect of intrathoracic pressure on left ventricular performance,” New England Journal of Medicine, vol. 301, no. 9, pp. 453–459, 1979. View at Google Scholar · View at Scopus
  5. K. Devulapally, R. Pongonis, and R. Khayat, “OSA: the new cardiovascular disease: part II: overview of cardiovascular diseases associated with obstructive sleep apnea,” Heart Failure Reviews, vol. 14, no. 3, pp. 155–164, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Garpestad, H. Katayama, J. A. Parker et al., “Stroke volume and cardiac output decrease at termination of obstructive apneas,” Journal of Applied Physiology, vol. 73, no. 5, pp. 1743–1748, 1992. View at Google Scholar · View at Scopus
  7. E. Garpestad, J. A. Parker, H. Katayama et al., “Decrease in ventricular stroke volume at apnea termination is independent of oxygen desaturation,” Journal of Applied Physiology, vol. 77, no. 4, pp. 1602–1608, 1994. View at Google Scholar · View at Scopus
  8. M. J. Hall, S. I. Ando, J. S. Floras, and T. D. Bradley, “Magnitude and time course of hemodynamic responses to Mueller maneuvers in patients with congestive heart failure,” Journal of Applied Physiology, vol. 85, no. 4, pp. 1476–1484, 1998. View at Google Scholar · View at Scopus
  9. Y. Kaneko, J. S. Floras, K. Usui et al., “Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea,” New England Journal of Medicine, vol. 348, no. 13, pp. 1233–1241, 2003. View at Google Scholar · View at Scopus
  10. A. Malhotra and J. Loscalzo, “Sleep and cardiovascular disease: an overview,” Progress in Cardiovascular Diseases, vol. 51, no. 4, pp. 279–284, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. S. M. Scharf, J. A. Bianco, D. E. Tow, and R. Brown, “The effects of large negative intrathoracic pressure on left ventricular function in patients with coronary artery disease,” Circulation, vol. 63, no. 4, pp. 871–875, 1981. View at Google Scholar · View at Scopus
  12. B. Shivalkar, C. Van De Heyning, M. Kerremans et al., “Obstructive sleep apnea syndrome: more insights on structural and functional cardiac alterations, and the effects of treatment with continuous positive airway pressure,” Journal of the American College of Cardiology, vol. 47, no. 7, pp. 1433–1439, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Stoohs and C. Guilleminault, “Cardiovascular changes associated with obstructive sleep apnea syndrome,” Journal of Applied Physiology, vol. 72, no. 2, pp. 583–589, 1992. View at Google Scholar · View at Scopus
  14. R. Tkacova, F. Rankin, F. S. Fitzgerald, J. S. Floras, and T. D. Bradley, “Effects of continuous positive airway pressure on obstructive sleep apnea and left ventricular afterload in patients with heart failure,” Circulation, vol. 98, no. 21, pp. 2269–2275, 1998. View at Google Scholar · View at Scopus
  15. F. A. Tolle, W. V. Judy, P. L. Yu, and O. N. Markand, “Reduced stroke volume related to pleural pressure in obstructive sleep apnea,” Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, vol. 55, no. 6, pp. 1718–1724, 1983. View at Google Scholar · View at Scopus
  16. J. W. Weiss, S. H. Launois, A. Anand, and E. Garpestad, “Cardiovascular morbidity in obstructive sleep apnea,” Progress in Cardiovascular Diseases, vol. 41, no. 5, pp. 367–376, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Goldman, “Age-dependent cardiopulmonary interaction during airway obstruction: a simulation model,” American Journal of Physiology, vol. 299, no. 5, pp. H1610–H1614, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Mukkamala, “A cardiovascular simulator for research,” in USer’s Manual and Software Guide, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Mass, USA, 2004. View at Google Scholar
  19. R. Mukkamala and R. J. Cohen, “A forward model-based validation of cardiovascular system identification,” American Journal of Physiology, vol. 281, no. 6, pp. H2714–H2730, 2001. View at Google Scholar · View at Scopus
  20. R. Mukkamala, G. B. Moody, and R. G. Mark, “Introduction of computational models to PhysioNet,” Computing in Cardiology, vol. 28, pp. 77–80, 2001. View at Google Scholar
  21. W. R. Condos, R. D. Latham, S. D. Hoadley, and A. Pasipoularides, “Hemodynamics of the Mueller maneuver in man: right and left heart micromanometry and Doppler echocardiography,” Circulation, vol. 76, no. 5, pp. 1020–1028, 1987. View at Google Scholar · View at Scopus
  22. K. Campbell, M. Zeglen, T. Kagehiro, and H. Rigas, “A pulsatile cardiovascular computer model for teaching heart-blood vessel interaction,” Physiologist, vol. 25, no. 3, pp. 155–162, 1982. View at Google Scholar · View at Scopus
  23. F. M. Melchior, R. S. Srinivasan, and J. B. Charles, “Mathematical modeling of human cardiovascular system for simulation of orthostatic response,” American Journal of Physiology, vol. 262, no. 6, pp. H1920–H1933, 1992. View at Google Scholar · View at Scopus
  24. J. J. Van Lieshout, M. P. M. Harms, F. Pott, M. Jenstrup, and N. H. Secher, “Stroke volume of the heart and thoracic fluid content during head-up and head-down tilt in humans,” Acta Anaesthesiologica Scandinavica, vol. 49, no. 9, pp. 1287–1292, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. J. M. John, M. Haykowsky, P. Brubaker, K. Stewart, and D. W. Kitzman, “Decreased left ventricular distensibility in response to postural change in older patients with heart failure and preserved ejection fraction,” American Journal of Physiology, vol. 299, no. 3, pp. H883–H889, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. M. D. Nelson, L. A. Altamirano-Diaz, S. R. Petersen et al., “Left ventricular systolic and diastolic function during tilt-table positioning and passive heat stress in humans,” American Journal of Physiology, vol. 301, no. 2, pp. H599–H608, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Heldt, E. B. Shim, R. D. Kamm, R. G. Mark, and Massachusetts, “Computational modeling of cardiovascular response to orthostatic stress,” Journal of Applied Physiology, vol. 92, no. 3, pp. 1239–1254, 2002. View at Google Scholar · View at Scopus