Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives

Table 1

Inhibitory activity of 1,3,4-oxadiazoles derivatives against Jack bean urease.

Compound	IC50 ± SEM (μM) (or % inhibition)
4a	5.79 ± 0.3
4b	21.3 ± 0.7
4c	11.8 ± 0.4
4e	11.3 ± 0.6
4f	3.27 ± 0.3
4g	5.61 ± 0.3
4h	42.4 ± 1.2
4i	6.22 ± 0.4
4j	1.15 ± 0.2
4k	12.9 ± 0.6
4l	5.83 ± 0.08
4m	5.60 ± 0.6
4n	12.2 ± 0.05
4o	15.1 ± 0.8
4r	(39)^a
Thiourea (standard)	22.3 ± 1.2

^a% age inhibition was evaluated using inhibitor at a concentration of 100 μM.