T-817MA, but Not Haloperidol and Risperidone, Restores Parvalbumin-Positive γ-Aminobutyric Acid Neurons in the Prefrontal Cortex and Hippocampus of Rats Transiently Exposed to MK-801 at the Neonatal Period

Figure 3

Effect of 14-day (PD 49–62) treatment with T-817MA, HPD, or RPD on the density of PV-positive GABAergic interneuron cells (cells/mm²) in the hippocampus in rats that did or did not receive neonatal treatment with MK-801. DW group (𝑛=12), HPD group (𝑛=10), RPD group (𝑛=10), and T-817MA group (𝑛=11) treated neonatally with saline are shown in the left side. DW group (𝑛=9), HPD group (𝑛=11), RPD group (𝑛=11), and T-817MA group (𝑛=9) treated neonatally with MK-801 are shown in the right side. Data of saline group (open bars), HPD group (dark bars), RPD group (shaded bars), and T-817MA group (closed bars) are shown. Values are expressed as means ± SEM. ^#; 𝑃<0.05 as compared with saline-DW group. *; 𝑃<0.05 as compared with MK801-DW group.