Research Article

Sterculic Oil, a Natural SCD1 Inhibitor, Improves Glucose Tolerance in Obese ob/ob Mice

Table 2

Plasma characteristics of wild-type (WT) and ob/ob (OB) mice receiving an AIN-93G diet (AIN) or a sterculic oil-supplemented diet (SO)1.

value2
WT AINWT SOOB AINOB SOdgd × g

Plasma lipids (mg/dL)
 Triglyceride 117.1 ±12.087.5 ± 7.1118.3 ± 3.1122.2 ± 11.30.1860.0710.097
 Total cholesterol 145.2 ± 6.6136.5 ± 4.5324.3 ± 7.6290.0 ± 12.5<0.05<0.0010.138
 HDL-C 63.7 ± 8.168.7 ± 2.7103.8 ± 4.292.0 ± 3.80.598<0.0010.165
 LDL-C 21.2 ± 2.025.5 ± 3.272.8 ± 2.874.8 ± 3.50.301<0.0010.700
 NEFA (mmol/L) 1.4 ± 0.11.2 ± 0.11.1 ± 0.11.2 ± 0.20.7180.2890.280
Plasma IL-6 (pg/mL)96.9 ± 52.051.0 ± 15.867.8 ± 38.9285.3 ± 52.00.4540.0470.138

1Data are presented as means ± SEM with = 5–7 per group.
2Data were analyzed by 2-way ANOVA with diet (SO or AIN) as one factor and the phenotype (WT or OB) as the second factor. -values are for an effect of diet (d), an effect of the genotype (g), or an interaction between the two (d × g).