Table of Contents
ISRN Endocrinology
Volume 2012, Article ID 949427, 6 pages
Clinical Study

Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome

1Clinical Biochemistry, Metabolic Diseases Research Center, Zajan University of Medical Sciences, 451398-6745 Zanjan, Iran
2Clinical Endocrinology, Metabolic Diseases Research Center, Zajan University of Medical Sciences, 451398-6745 Zanjan, Iran
3Department of Biochemistry, Payame Noor University, Tehran, Iran
4Biochemistry, Zanjan University of Medical Sciences, Zanjan, Iran
5Epidemiology, Zanjan Metabolic Diseases Research Center, Zanjan, Iran

Received 4 October 2011; Accepted 29 November 2011

Academic Editors: S. M. Hileman, M. Hiriart, Y. B. Lombardo, and H. Ueshiba

Copyright © 2012 Sahar Mazloomi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate the possible association of calcium and vitamin D deficiency with hypoadiponectinemia in women with PCOS. Subjects and Methods. In this case-control study, 103 PCOS cases and 103 controls included. The concentrations of calcium, 25-OH-vitamin D (25OHD), adiponectin, insulin, glucose, total cholesterol, HDL-cholesterol, triglyceride (TG), and androgens were measured in fasting blood samples. Results. Adiponectin (8.4±2.7 ng/mL versus 13.6±5 ng/mL in control group, 𝑃0.00), calcium (2±0.1 mmol/L versus 2.55±0.17 mmol/L in controls, 𝑃0.00), and 25-OH-Vit D (30±2.99 nmol/L versus 43.7±5.2 nmol/L in control group, 𝑃0.00) levels were decreased in women with PCOS. Subjects with PCOS had higher concentrations of TG (1.4±0.77 mmol/L versus 1.18±0.75 mmol/L in control group, 𝑃0.019) and dehydroepiandrosterone sulfate (DHEA-S) (10.7±11 mmol/L versus 9.7±10.4, 𝑃0.02 in control group). There were significant correlations between adiponectin concentrations with calcium (𝑟0.78, 𝑃0.00) and 25OHD levels (𝑟0.82, 𝑃0.00). The association of hypoadiponectinemia and PCOS was not significant considering 25OHD as a confounding factor. Conclusion. The present findings indicate that the association of hypoadiponectinemia with PCOS is dependent on vitamin D. A possible beneficiary effect of vitamin D on the metabolic parameters in PCOS may be suggested.