Clinical Study
Ovarian Reserve in Women Treated for Acute Lymphocytic Leukemia or Acute Myeloid Leukemia with Chemotherapy, but Not Stem Cell Transplantation
Table 2
Timing of chemotherapy, hormonal treatments, and menstrual change.
| Subject | Age | Time since chemotherapy (years) | Time between menarche and chemotherapy (years) | Menstrual change during chemotherapy | Time to return of menses (months) | Duration of COC (months) | Duration of GnRH agonist (months) | Menstrual change after chemotherapy |
| 1 | 39 | 3.7 | 23 | Stopped | 9–12 | 0 | Unknown | Lighter | 2 | 33 | 4.0 | 18 | Stopped | <1 | 0.5 | 3 | Restarted and returned to normal | 3 | 33 | 2.4 | 18 | Stopped | >12 | 0 | 31 | Restarted and returned to normal | 4 | 27 | 0.5 | 14 | More frequent | <1 | 24 | 6 | Lighter | 5 | 25 | 1.8 | 12 | Stopped | 6–9 | 0 | 24 | Lighter |
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COC: combined oral contraception. GnRH agonist: gonadotropin releasing hormone agonist.
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