Effects of a Physical Activity Program on Markers of Endothelial Dysfunction, Oxidative Stress, and Metabolic Status in Adolescents with Metabolic Syndrome

Table 3

Baseline markers of inflammation, endothelial dysfunction, and oxidative stress in adolescents.

	Women (𝑛=18)			Men (𝑛=20)
	Mean (SD)			Mean (SD)
	With MetS	Without MetS	𝑃^∗	With MetS	Without MetS	𝑃^∗
Markers of inflammation
hsCRP	0.16 (0.13)	0.07 (0.04)	0.100	0.09 (0.06)	0.13 (0.08)	0.244
Fg	457 (138)	377 (163)	0.326	438 (177)	417 (141)	0.793
Markers of endothelial cell dysfunction
PAI-1	37.2 (11)	27.4 (8.9)	0.102	39.2 (5.7)	38.9 (10)	0.937
tPA	5.8 (2.9)	3.2 (1.3)	0.066	4.4 (1.8)	4.9 (2.4)	0.573
vWF	144 (27)	129 (28)	0.308	146 (26)	150 (37)	0.753
FVIII	121 (24)	112 (32)	0.560	112 (27)	134 (42)	0.203
sVCAM-1	17.4 (6.1)	22.8 (14)	0.307	26.9 (17)	19.9 (5.6)	0.374
P-selectin	24.4 (4.7)	20.0 (5.3)	0.119	22.4 (10)	24.0 (8.9)	0.748
Markers of oxidative stress
Lpox	518 (119)	663 (168)	0.083	605 (223)	589 (269)	0.893
SOD	341 (237)	876 (399)	0.008	681 (385)	510 (709)	0.530
Cat	16.8 (13)	19.9 (16)	0.699	15.4 (14)	13.4 (8.6)	0.746
Gpox	964 (1282)	513 (678)	0.451	2303 (2225)	3792 (3869)	0.328
SOD/Gpox + Cat	17.8 (13)	24.0 (18)	0.475	16.1 (14)	15.1 (11)	0.874

hsCRP: high-sensitivity C-reactive protein (mg/dL); Fg: fibrinogen (mg/dL); PAI-1: plasminogen activator inhibitor type 1 (ng/mL); tPA: tissue plasminogen activator (ng/mL); vWF: von Willebrand factor (U/mL); FVIII: factor VIII (%); sVCAM-1: soluble vascular cell adhesion molecule-1 (U/mL); P-selectin (U/mL); Lpox: lipoperoxidation (nMol MDA/gHb); SOD: superoxide dismutase (μMol adrenalin/gHb); Cat: catalase (μMol H₂O₂/gHb); Gpox: glutathione peroxidase (μMol NADPH/gHb). ^*Sudent's 𝑡-test.