Table of Contents
ISRN Pulmonology
Volume 2012, Article ID 973203, 6 pages
http://dx.doi.org/10.5402/2012/973203
Clinical Study

Implication of DNA Methylation Profiling in Oral Epithelium for Lung Cancer Screening

1Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8553, Japan
2Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure 737-0023, Japan
3Department of Respiratory Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure 737-0023, Japan
4Department of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima 737-0023, Japan
5Department of Respiratory Medicine, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure 737-0023, Japan
6Department of Surgery, Hitoyoshi General Hospital, Hitoyoshi 868-0053, Japan
7Programs for Biomedical Research, Division of Frontier Medical Sciences, Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8553, Japan

Received 15 October 2012; Accepted 30 October 2012

Academic Editors: B. Antus, A. Celi, C. Flores, and J. Ho

Copyright © 2012 Hiroaki Harada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. T. Greenlee, M. B. Hill-Harmon, T. Murray, and M. Thun, “Cancer Statistics, 2001,” Ca-A Cancer Journal for Clinicians, vol. 51, no. 1, pp. 15–36, 2001. View at Google Scholar · View at Scopus
  2. P. A. Wingo, L. A. G. Ries, G. A. Giovino et al., “Annual report to the nation on the status of cancer, 1973–1996, with a special section on lung cancer and tobacco smoking,” Journal of the National Cancer Institute, vol. 91, no. 8, pp. 675–690, 1999. View at Google Scholar · View at Scopus
  3. T. Blanchon, J. M. Bréchot, P. A. Grenier et al., “Baseline results of the Depiscan study: a French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR),” Lung Cancer, vol. 58, no. 1, pp. 50–58, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. P. B. Bach, G. A. Silvestri, M. Hanger, and J. R. Jett, “Screening for lung cancer: ACCP evidence-based clinical practice guidelines,” Chest, vol. 132, no. 3, pp. S69–S77, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. D. R. Aberle, A. M. Adams, C. D. Berg et al., “Reduced lung-cancer mortality with low-dose computed tomographic screening,” New England Journal of Medicine, vol. 365, no. 5, pp. 395–409, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. J. Alberg, M. V. Brock, and J. M. Samet, “Epidemiology of lung cancer: looking to the future,” Journal of Clinical Oncology, vol. 23, no. 14, pp. 3175–3185, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. H. E. Gabriel, J. W. Crott, H. Ghandour et al., “Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults,” American Journal of Clinical Nutrition, vol. 83, no. 4, pp. 835–841, 2006. View at Google Scholar · View at Scopus
  8. H. W. Chang, G. S. Ling, W. I. Wei, and A. P. W. Yuen, “Smoking and drinking can induce p15 methylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma,” Cancer, vol. 101, no. 1, pp. 125–132, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. C. V. Breton, H. M. Byun, M. Wenten, F. Pan, A. Yang, and F. D. Gilliland, “Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation,” American Journal of Respiratory and Critical Care Medicine, vol. 180, no. 5, pp. 462–467, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. G. Herman and S. B. Baylin, “silencing in cancer in association with promoter hypermethylation,” New England Journal of Medicine, vol. 349, no. 21, pp. 2042–2054, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. T. A. Rauch, Z. Wang, X. Wu, K. H. Kernstine, A. D. Riggs, and G. P. Pfeifer, “DNA methylation biomarkers for lung cancer,” Tumor Biology, vol. 33, no. 2, pp. 287–296, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. M. V. Brock, C. M. Hooker, E. Ota-Machida et al., “DNA methylation markers and early recurrence in stage I lung cancer,” New England Journal of Medicine, vol. 358, no. 11, pp. 1118–1128, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. K. L. Ostrow, M. O. Hoque, M. Loyo et al., “Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR,” Clinical Cancer Research, vol. 16, no. 13, pp. 3463–3472, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Topaloglu, M. O. Hoque, Y. Tokumaru et al., “Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer,” Clinical Cancer Research, vol. 10, no. 7, pp. 2284–2288, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. W. Han, T. Wang, A. A. Reilly, S. M. Keller, and S. D. Spivack, “Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patients,” Respiratory Research, vol. 10, article no. 86, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Watanabe, H. S. Kim, R. J. Castoro et al., “Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes,” Gastroenterology, vol. 136, no. 7, pp. 2149–2158, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Maekita, K. Nakazawa, M. Mihara et al., “High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk,” Clinical Cancer Research, vol. 12, no. 3, part 1, pp. 989–995, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Miyamoto, K. Asada, T. Fukutomi et al., “Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers,” Oncogene, vol. 22, no. 2, pp. 274–280, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. J. G. Herman, J. R. Graff, S. Myohanen, B. D. Nelkin, and S. B. Baylin, “Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 18, pp. 9821–9826, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Miyamoto, T. Fukutomi, S. Akashi-Tanaka et al., “Identification of 20 genes aberrantly methylated in human breast cancers,” International Journal of Cancer, vol. 116, no. 3, pp. 407–414, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Furuta, Y. Umebayashi, K. Miyamoto et al., “Promoter methylation profiling of 30 genes in human malignant melanoma,” Cancer Science, vol. 95, no. 12, pp. 962–968, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. S. A. Belinsky, “Gene-promoter hypermethylation as a biomarker in lung cancer,” Nature Reviews Cancer, vol. 4, no. 9, pp. 707–717, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Bhutani, A. K. Pathak, Y. H. Fan et al., “Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs,” Cancer Prevention Research, vol. 1, no. 1, pp. 39–44, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Wu, T. A. Rauch, X. Zhong et al., “CpG Island hypermethylation in human astrocytomas,” Cancer Research, vol. 70, no. 7, pp. 2718–2727, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Funahashi, Y. Okada, H. Sawai et al., “The role of glial cell line-derived neurotrophic factor (GDNF) and integrins for invasion and metastasis in human pancreatic cancer cells,” Journal of Surgical Oncology, vol. 91, no. 1, pp. 77–83, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Garnis, J. J. Davies, T. P. H. Buys et al., “Chromosome 5p aberrations are early events in lung cancer: implication of glial cell line-derived neurotrophic factor in disease progression,” Oncogene, vol. 24, no. 30, pp. 4806–4812, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. P. P. Anglim, J. S. Galler, M. N. Koss et al., “Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer,” Molecular Cancer, vol. 7, article no. 62, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. Q. Feng, S. E. Hawes, J. E. Stern et al., “DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 3, pp. 645–654, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. J. H. Chung, H. J. Lee, B. H. Kim, N. Y. Cho, and G. H. Kang, “DNA methylation profile during multistage progression of pulmonary adenocarcinomas,” Virchows Archiv, vol. 459, no. 2, pp. 1–11, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Shivapurkar, M. E. Sherman, V. Stastny et al., “Evaluation of candidate methylation markers to detect cervical neoplasia,” Gynecologic Oncology, vol. 107, no. 3, pp. 549–553, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. W. A. Palmisano, K. K. Divine, G. Saccomanno et al., “Predicting lung cancer by detecting aberrant promoter methylation in sputum,” Cancer Research, vol. 60, no. 21, pp. 5954–5958, 2000. View at Google Scholar · View at Scopus