Table of Contents
ISRN Hematology
Volume 2012, Article ID 986795, 10 pages
Clinical Study

The Effects of Continuous Blood Purification for SIRS/MODS Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

1Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
2The Second Hospital of Lanzhou University, Lanzhou 730000, China
3The First Hospital of Lanzhou University, Lanzhou 730000, China
4Peking Union Medical College Hospital, Beijing 100730, China

Received 4 April 2012; Accepted 2 May 2012

Academic Editors: D. Del Principe and I. C. Haznedaroglu

Copyright © 2012 Tian Hongliang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Continuous veno-venous hemofiltration (CVVH) has aroused great concern in recent years because its effect on clearing inflammatory mediators and its mechanism of clinical effects in the treatment of critical illness has also become a research direction. Objective. To evaluate the efficacy of continuous blood purification for systemic inflammatory response syndrome (SIRS)/multiple organ dysfunction syndrome (MODS) patients. Methods. A systematic review of the literature was undertaken to assess randomized controlled trials on CVVH. Results. 11 RCTs involving a total of 414 patients were included. Compared with the control group, CVVH for SIRS/MODS patients has several advantages including better effects on clearing the plasma inflammatory mediators IL-6 [ , 95%CI, (−0.83, −0.07), , 95%CI, (−1.52, −0.62)], on plasma TNF-alfa [ , 95%CI, (−1.69, −0.04), , 95%CI, (−2.49, −0.35)], lower white blood cell (WBC) count [ , 95%CI, (1.49, 3.73)], shorter hospital stays [ days, 95%CI, (−10.68, −3.74)] and better stability of hemodynamics. However, there is no significant difference in the mortality rate [MODS: , 95%CI, (0.38, 1.01), SIRS: , 95%CI, (0.57, 1.08)]. Conclusions. The study showed that CVVH was able to eliminate inflammatory mediators (TNF-alfa, IL-6) in plasma effectively, lower WBC count and shorter hospital stays than conventional therapeutic measures.