Table of Contents
ISRN Obstetrics and Gynecology
Volume 2013 (2013), Article ID 104213, 5 pages
http://dx.doi.org/10.1155/2013/104213
Research Article

Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Nitric Oxide Metabolite Levels in Preeclampsia Patients

1Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran
2Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan 81745, Iran
3Nursing & Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran
4Department of Midwifery, Isfahan University of Medical Sciences, Isfahan 81745, Iran
5Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745, Iran
6Isfahan-MN Institute of Basic & Applied Sciences Research, Isfahan 81546, Iran

Received 6 June 2013; Accepted 24 July 2013

Academic Editors: M. Kühnert and S. Palomba

Copyright © 2013 Marjan Noorbakhsh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Hypertensive disorder generally complicates 5–10 percent of all pregnancies. Angiogenic growth factors may be helpful for the diagnosis and prediction of preeclampsia. Therefore, in this study we attempted to determine the serum levels of asymmetric dimethylarginine (ADMA), vascular endothelial growth factor (VEGF), and nitric oxide (NO) metabolite (nitrite) in preeclampsia patients and compared the levels with those obtained from normal pregnant women. Methods. Ninety pregnant women (19–33 years old) in two groups of preeclampsia and normal were considered during 2012. The levels of ADMA, VEGF, and nitrite were measured in maternal serum samples using ELISA kits. Results. Significant increase of VEGF and nitrite levels was observed in preeclampsia patients when compared with other groups ( ). The serum level of ADMA demonstrated a similar increased trend in preeclampsia patients; however, the increase was not statistically significant ( ). Conclusion. The findings reveal that the elevation of serum levels of VEGF and nitrite and possibly ADMA may be involved in the pathogenesis of preeclampsia.