Research Article

Aryl Hydrocarbon Receptor Ligands Inhibit IGF-II and Adipokine Stimulated Breast Cancer Cell Proliferation

Figure 2

AHR ligands inhibit adipo-CM and IGF-2 stimulated breast cancer cell growth. (a, b) The total number of live MCF-7 (a) and T-47D (b) cells treated with DMSO vehicle or TCDD in fibro-CM or adipo-CM for three days in culture was determined and is displayed relative to the number of live cells in the fibro-CM DMSO control group, which was arbitrarily assigned a value of 1. Data shown are the means ± S.E. for three experiments, and a significant ( ) decrease in cell number by TCDD (*) is indicated. (c, d) The total number of MCF-7 (c) and T47D (d) cells treated with DMSO or TCDD alone or plus IGF-2 (100 ng/mL) for three days in culture was determined and is displayed relative to the number of live cells in the DMSO group, which was assigned a value of 1. Data shown are the means ± S.E. for three experiments, and a significant ( ) decrease in cell number by TCDD (*) is indicated. (e, f) The total number of MCF-7 cells stimulated with DMSO or SU5416 in fibro-CM or adipo-CM (e) or with DMSO or SU5416 alone or plus IGF-2 (100 ng/mL) for three days in culture was determined and is displayed relative to the number of live cells in the DMSO group, which was assigned a value of 1. Data shown are the means ± S.E. for three experiments, and a significant ( ) decrease in cell number by TCDD (*) is indicated.
104850.fig.002a
(a)
104850.fig.002b
(b)
104850.fig.002c
(c)
104850.fig.002d
(d)
104850.fig.002e
(e)
104850.fig.002f
(f)