Increased Resistance of Breast, Prostate, and Embryonic Carcinoma Cells against Herpes Simplex Virus in Three-Dimensional Cultures
Figure 2
Schematic models of MCF-10A, MB-231, PC-3, and P19 cells growing under 3D culture conditions. MCF-10A cells form compact aggregates on the surface of the matrix without invading cells. MB-231 cells form monolayers and loose aggregates on the Matrigel surface and individual tumor cells invade the matrix from the surface as the cultures age. Similarly to MB-231 cells, PC-3 cells form aggregates on the matrix-surface and individual cells migrate into the gel as cultures age although matrix invasion is slower. P19 cells form tube-like structures reminiscent of vasculogenic mimicry patterns on the surface of the matrix, and later individual tumor cells invade the matrix in the proximity of vasculogenic mimicry patterns.
