Development and Evaluation of Gastroretentive Floating Tablets of an Antihypertensive Drug Using Hydrogenated Cottonseed Oil

Table 2

Precompression parameters of designed formulations (F1–F17).

Formulation code	Precompression evaluation parameters
	Bulk density (mg/mL)	Tapped density (mg/mL)	Carr's index	Angle of repose	Hausner's ratio
	(𝑛=3) Mean ± SD	(𝑛=3) Mean ± SD	(%)	(𝑛=3) Mean ± SD
F1	0.384±0.009	0.5±0.010	23.08	23.01±1.289	1.13
F2	0.4081±0.007	0.5±0.012	18.38	27.02±1.30	1.22
F3	0.4545±0.006	0.52631±0.014	13.64	22.29±0.912	1.55
F4	0.4166±0.010	0.52631±0.011	15.56	28.36±1.344	1.18
F5	0.4233±0.004	0.4825±0.013	12.4	28.1±1.23	1.14
F6	0.4324±0.009	0.5059±0.008	15.7	28.1±1.45	1.17
F7	0.4256±0.008	0.4809±0.015	12.8	27.6±0.82	1.13
F8	0.4065±0.011	0.4837±0.011	15.9	29.32±1.23	1.19
F9	0.4324±0.009	0.4886±0.009	12.8	27.6±1.66	1.13
F10	0.4065±0.007	0.4837±0.012	12.3	29.36±1.25	1.19
F11	0.4546±0.006	0.5227±0.014	11.2	28.76±1.33	1.15
F12	0.4166±0.009	0.4915±0.012	11.3	26.74±0.911	1.18
F13	0.4324±0.011	0.48861±0.009	12.2	25.3±1.155	1.13
F14	0.4088±0.006	0.4782±0.010	11.5	28.7±0.81	1.17
F15	0.4632±0.005	0.528±0.011	14.7	28±1.43	1.14
F16	0.4321±0.009	0.4882±0.012	15.7	29.2±1.234	1.13
F17	0.4776±0.007	0.5667±0.014	16.9	28.67±1.33	1.14
F18	0.486±0.005	0.523±0.012	11.5	27.34±1.55	1.13