Development and Evaluation of Gastroretentive Floating Tablets of an Antihypertensive Drug Using Hydrogenated Cottonseed Oil

Table 6

The in vitro drug release profiles for the formulations (F1–F8).

Time (hrs)	F1	F2	F3	F4	F5	F6	F7	F8
0	0	0	0	0	0	0	0	0
1	27.92±0.65	30.23±0.45	24.45±0.90	21.34±0.84	24.44±0.55	25.34±0.56	21.33±0.78	20.22±0.60
2	73.9±0.77	55.65±0.60	33.21±0.67	29.35±0.67	35.31±1.45	36.42±1.34	31.7±0.60	34.75±0.78
3	83.46±0.77	72.05±0.34	41.17±0.45	34.65±0.57	44.54±0.60	42.3±0.45	35.01±0.66	42.37±0.66
4	87.17±0.25	78.22±0.67	55.15±0.55	38.12±0.34	52.62±0.78	53.12±1.45	48.56±1.45	50.63±0.45
5	89.89±0.95	83.29±0.56	61.91±0.56	40.76±0.88	63.71±0.33	58.63±0.56	56.86±0.48	55.16±0.55
6	90.96±0.46	86.61±0.89	66.81±0.45	44.58±0.33	69.41±0.89	65.36±0.88	61.72±0.34	58.94±0.95
7	93.08±0.60	90.21±1.23	71.67±0.88	48.82±0.45	75.13±0.55	70.93±0.60	66.39±0.56	64.46±0.88
8	94.29±0.34	92.16±0.56	74.56±0.25	51.44±0.77	80.87±0.45	78.03±0.34	72.66±0.66	68.12±0.93
9	99.06±0.45	94.61±0.60	76.09±0.89	56.09±0.23	94.77±0.23	85.36±0.33	76.46±0.90	72.8±0.67
10	—	96.54±0.23	80.28±0.24	61.43±1.33	98.01±0.34	91.73±0.56	82.62±0.55	76.34±0.34
11	—	98.69±0.45	83.4±1.23	65.08±0.33	—	94.55±0.99	89.33±0.78	81.6±0.66
12	—	—	—	71.23±0.45	—	97.13±1.24	92.75±0.88	86.49±0.45

∗All above reading are average ± SD, 𝑛=6.