Motor Skill Training Promotes Sensorimotor Recovery and Increases Microtubule-Associated Protein-2 (MAP-2) Immunoreactivity in the Motor Cortex after Intracerebral Hemorrhage in the Rat
Figure 1
(a) Graphic representation of numbers of pellets consumed. Pellets from the first steps (1st to 4th) and from deeper steps (5th to 7th) over time. S (sham), ICH (intracerebral hemorrhage), SK (skilled training), and US (unskilled training). Data are presented as mean ± standard error (SEM). Dotted line represents minimum criteria of pellets retrieved for inclusion of animals in the study. Data are presented as mean ± standard error (SEM). (b) (A) Representative brain slice stained with MAP-2 showing areas of the interest (AOI) used to determine M1 optical density. (B) Representative area showing MAP-2 staining. (C) Relative optical density of MAP-2 staining in ipsilesional M1: “a” differences between S and S-SK (), ICH (), ICH-SK, and ICH-US (); “b” difference between S-US and ICH-SK (), and ICH-US (); “c” difference between ICH and ICH-SK (). (D) Relative optical density of MAP-2 staining in contralesional M1: “a” difference between S and S-SK, ICH, ICH-SK (), and ICH-US (); “b” difference between S-US and ICH-SK (); “d” difference between ICH-SK and ICH-US (). S (sham), ICH (intracerebral hemorrhage), SK (skilled training), and US (unskilled training). Data are presented as mean ± standard error (SEM).
