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Research Article

Mouse Models and Techniques for the Isolation of the Diabetic Endothelium

Table 4

(a) Transcripts dysregulated <−0.75 or >0.75 log₂ fold in the aortic endothelium of ApoE(−/−)/GFP mice after 4 weeks of high-fat diet versus chow diet. (b) Transcripts dysregulated <−0.75 or >0.75 log₂ fold in the skeletal muscle endothelium of ApoE(−/−)/GFP mice after 4 weeks of high-fat diet versus chow diet.

(a)


RefSeq	Description	Gene symbol	Log₂ fold change	value

NM_008134	Glycosylation-dependent cell adhesion molecule 1	Glycam1	2.539	0.01
NM_010382	Histocompatibility 2, class II antigen E beta	H2-Eb1	2.22	0.01
NM_011498	Basic helix-loop-helix domain containing, class B2	Bhlhb2	1.388	0.05
NM_011693	Vascular cell adhesion molecule 1	Vcam1	1.377	0.03
NM_019414	Selenium-binding protein 2	Selenbp2	1.228	0.04
NM_007929	Epithelial membrane protein 2	Emp2	1.211	0.02
NM_013904	Hairy/enhancer-of-split-related with YRPW motif 2	Hey2	1.188	0.05
NM_023117	Cell division cycle 25 homolog B (S. cerevisiae)	Cdc25b	1.164	0.04
NM_145144	RIKEN cDNA 2810003C17 gene	2810003C17Rik	1.112	0.02
XM_128002	Collagen triple helix repeat containing 1	Cthrc1	1.095	0.01
NM_007554	Bone morphogenetic protein 4	Bmp4	1.082	0.01
NM_175397	RIKEN cDNA 5830484A20 gene	5830484A20Rik	1.042	0.02
XM_484254	Extracellular matrix protein 2	Ecm2	1.032	0.03
NM_008357	Interleukin 15, transcript variant 1, mRNA	Il15	0.993	0.05
NM_022004	FXYD domain-containing ion transport regulator 6	Fxyd6	0.976	0.03
XM_133801	Golgi associated, gamma adapt-in ear containing, ARF-binding protein 2	Gga2	0.933	0.03
NM_138587	Family with sequence similarity 3, member C	fam3c	0.924	0.04
NM_025809	C-type lectin domain family 14, member a	Clec14a	0.911	0.02
NM_013750	Pleckstrin homology-like domain, family A, member 3	Phlda3	0.899	0.03
NM_008330	Interferon gamma inducible protein 47	Ifi47	0.892	0.04
XM_140320	Coiled-coil domain containing 112	Ccdc112	0.879	0.03
NM_133663	Integrin beta 4	Itgb4	0.879	0.02
NM_025443	Partner of NOB1 homolog (S. cerevisiae)	Pno1	0.875	0.03
NM_007722	Chemokine (C-X-C motif) receptor 7	Cxcr7	0.875	0.01
XM_485110	RIKEN cDNA 2210418O10 gene	2210418O10Rik	0.87	0.02
NM_009463	Uncoupling protein 1 (mitochondrial, proton carrier)	Ucp1	0.857	0.04
NM_177618	cDNA sequence BC030477	BC030477	0.856	0.02
NM_183259	RIKEN cDNA 2210020M01 gene	2210020M01Rik	0.83	0.02
NM_010514	Insulin-like growth factor 2	Igf2	0.819	0.04
NM_010424	Hemochromatosis	Hfe	0.815	0.03
NM_177325	TSR1, 20S rRNA accumulation, homolog (yeast)	Tsr1	0.814	0.02
NM_001004062	CREB-regulated transcription coactivator 1	Crtc1	0.802	0.01
NM_133964	Deoxyhypusine hydroxylase/monooxygenase	Dohh	0.797	0.00
NM_212445	KDEL (Lys-Asp-Glu-Leu) containing 2	Kdelc2	0.795	0.03
NM_027334	UbiE-YGHL1 fusion protein	Ubie	0.768	0.02
NM_008610	Matrix metallopeptidase 2	Mmp2	0.765	0.03
NM_009024	Retinoic acid receptor, alpha	Rara	0.759	0.04
NM_008659	Myosin IC	Myo1c	−0.818	0.00
NM_001002239	Ribosomal protein L17, mRNA	Rpl17	−0.85	0.02
NM_146011	Rho GTPase activating protein 9	Arhgap9	−0.872	0.01
NM_020261	Pregnancy-specific glycoprotein 23	Psg23	−0.874	0.01
NM_016892	Copper chaperone for superoxide dismutase	Ccs	−0.905	0.02
NM_021469	Dysferlin	Dysf	−0.943	0.04
NM_027015	Ribosomal protein S27	Rps27	−1.174	0.02
NM_010826	MRV integration site 1	Mrvi1	−1.218	0.01
NM_007913	Early growth response 1	Egr1	−1.423	0.01
NM_017398	Diaphanous homolog 2 (Drosophila)	Diap2	−1.485	0.04

(b)


RefSeq	Description	Gene symbol	Log₂ fold change	value

NM_025557	Purkinje cell protein 4-like 1	Pcp4l1	1.988	0.01
NM_008250	H2.0-like homeo box 1 (Drosophila)	Hlx1	1.544	0.05
NM_013549	Histone cluster 2, H3c2	Hist2h3c2	1.536	0.01
NM_011620	Troponin T3, skeletal, fast	Tnnt3	1.426	0.04
NM_029688	Sulfiredoxin 1 homolog (S. cerevisiae)	Srxn1	1.335	0.03
NM_026095	Small nuclear ribonucleoprotein D3	Snrpd3	1.277	0.04
NM_010382	Histocompatibility 2, class II antigen E beta	H2-Eb1	1.264	0.02
NM_008162	Glutathione peroxidase 4	Gpx4	1.221	0.02
XM_488375	Similar to barrier to autointegration factor 1 (LOC385407)	—	1.215	0.02
NM_007507	ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e	Atp5k	1.199	0.01
NM_011313	S100 calcium-binding protein A6 (calcyclin)	S100a6	1.197	0.02
XM_128110	Polymerase (RNA) II (DNA directed) polypeptide F	Polr2f	1.195	0.00
NM_207648	Histocompatibility 2, Q region locus 6	H2-Q6	1.176	0.01
NM_010361	Glutathione S-transferase, theta 2	Gstt2	1.166	0.01
NM_181316	RIKEN cDNA E130103I17 gene	E130103I17Rik	1.136	0.03
NM_011119	Proliferation-associated 2G4	Pa2g4	1.119	0.03
NM_153152	RIKEN cDNA 2410015M20 gene	2410015M20Rik	1.086	0.01
NM_053078	DNA segment, human D4S114 (D0H4S114), transcript variant 1	—	1.065	0.04
NM_013706	CD52 antigen	Cd52	1.047	0.02
NM_026616	Ribonuclease H2, subunit C	Rnaseh2c	1.044	0.01
NM_011289	Ribosomal protein L27	Rpl27	1.02	0.01
XM_109683	RIKEN cDNA 1810027O10 gene	1810027O10Rik	1.006	0.02
NM_018832	PDZ domain containing, X chromosome	Pdzx	1.003	0.02
NM_024171	Sec61 beta subunit	Sec61b	0.95	0.02
NM_009081	Ribosomal protein L28	Rpl28	0.95	0.04
NM_008210	H3 histone, family 3A	H3f3a	0.942	0.02
XM_193800	RIKEN cDNA 1500032L24 gene	1500032L24Rik	0.927	0.01
XM_489638	Ribosomal protein L26	Rpl26	0.91	0.04
NM_021407	Triggering receptor expressed on myeloid cells 3	Trem3	0.872	0.02
NM_009811	Caspase 6	Casp6	0.858	0.04
NM_011185	Proteasome (prosome, macropain) subunit, beta type 1	Psmb1	0.855	0.01
NM_008303	Heat shock protein 1 (chaperonin 10), related sequence 1	Hspe1-rs1	0.84	0.00
NM_019682	Dynein light chain LC8-type 1	Dynll1	0.836	0.04
XM_138368	Similar to Rpl7a protein (LOC217924)	—	0.816	0.02
NM_010174	Fatty-acid-binding protein 3, muscle and heart	Fabp3	0.813	0.03
NM_175399	Exosome component 4	Exosc4	0.81	0.04
NM_013498	Camp-responsive element modulator	Crem	0.802	0.00
NM_010394	Histocompatibility 2, Q region locus 7	H2-Q7	0.793	0.03
NM_011129	Septin 4	39329	0.785	0.04
NM_025396	6-Phosphogluconolactonase	Pgls	0.783	0.05
NM_212470	RIKEN cDNA 0610007C21 gene	0610007C21Rik	0.779	0.02
XM_133877	RIKEN cDNA 4933402N03 gene	4933402N03Rik	0.774	0.02
NM_011343	SEC61, gamma subunit	Sec61g	0.77	0.02
NM_025946	RIKEN cDNA 2010100O12 gene	2010100O12Rik	0.767	0.05
NM_025338	Aurora kinase A interacting protein 1	Aurkaip1	0.761	0.01
NM_009077	Ribosomal protein L18	Rpl18	0.753	0.05