Mouse Models and Techniques for the Isolation of the Diabetic Endothelium
Table 4
(a) Transcripts dysregulated <−0.75 or >0.75 log2 fold in the aortic endothelium of ApoE(−/−)/GFP mice after 4 weeks of high-fat diet versus chow diet. (b) Transcripts dysregulated <−0.75 or >0.75 log2 fold in the skeletal muscle endothelium of ApoE(−/−)/GFP mice after 4 weeks of high-fat diet versus chow diet.
(a)
RefSeq
Description
Gene symbol
Log2 fold change
value
NM_008134
Glycosylation-dependent cell adhesion molecule 1
Glycam1
2.539
0.01
NM_010382
Histocompatibility 2, class II antigen E beta
H2-Eb1
2.22
0.01
NM_011498
Basic helix-loop-helix domain containing, class B2
Bhlhb2
1.388
0.05
NM_011693
Vascular cell adhesion molecule 1
Vcam1
1.377
0.03
NM_019414
Selenium-binding protein 2
Selenbp2
1.228
0.04
NM_007929
Epithelial membrane protein 2
Emp2
1.211
0.02
NM_013904
Hairy/enhancer-of-split-related with YRPW motif 2
Hey2
1.188
0.05
NM_023117
Cell division cycle 25 homolog B (S. cerevisiae)
Cdc25b
1.164
0.04
NM_145144
RIKEN cDNA 2810003C17 gene
2810003C17Rik
1.112
0.02
XM_128002
Collagen triple helix repeat containing 1
Cthrc1
1.095
0.01
NM_007554
Bone morphogenetic protein 4
Bmp4
1.082
0.01
NM_175397
RIKEN cDNA 5830484A20 gene
5830484A20Rik
1.042
0.02
XM_484254
Extracellular matrix protein 2
Ecm2
1.032
0.03
NM_008357
Interleukin 15, transcript variant 1, mRNA
Il15
0.993
0.05
NM_022004
FXYD domain-containing ion transport regulator 6
Fxyd6
0.976
0.03
XM_133801
Golgi associated, gamma adapt-in ear containing, ARF-binding protein 2
Gga2
0.933
0.03
NM_138587
Family with sequence similarity 3, member C
fam3c
0.924
0.04
NM_025809
C-type lectin domain family 14, member a
Clec14a
0.911
0.02
NM_013750
Pleckstrin homology-like domain, family A, member 3
Phlda3
0.899
0.03
NM_008330
Interferon gamma inducible protein 47
Ifi47
0.892
0.04
XM_140320
Coiled-coil domain containing 112
Ccdc112
0.879
0.03
NM_133663
Integrin beta 4
Itgb4
0.879
0.02
NM_025443
Partner of NOB1 homolog (S. cerevisiae)
Pno1
0.875
0.03
NM_007722
Chemokine (C-X-C motif) receptor 7
Cxcr7
0.875
0.01
XM_485110
RIKEN cDNA 2210418O10 gene
2210418O10Rik
0.87
0.02
NM_009463
Uncoupling protein 1 (mitochondrial, proton carrier)
Ucp1
0.857
0.04
NM_177618
cDNA sequence BC030477
BC030477
0.856
0.02
NM_183259
RIKEN cDNA 2210020M01 gene
2210020M01Rik
0.83
0.02
NM_010514
Insulin-like growth factor 2
Igf2
0.819
0.04
NM_010424
Hemochromatosis
Hfe
0.815
0.03
NM_177325
TSR1, 20S rRNA accumulation, homolog (yeast)
Tsr1
0.814
0.02
NM_001004062
CREB-regulated transcription coactivator 1
Crtc1
0.802
0.01
NM_133964
Deoxyhypusine hydroxylase/monooxygenase
Dohh
0.797
0.00
NM_212445
KDEL (Lys-Asp-Glu-Leu) containing 2
Kdelc2
0.795
0.03
NM_027334
UbiE-YGHL1 fusion protein
Ubie
0.768
0.02
NM_008610
Matrix metallopeptidase 2
Mmp2
0.765
0.03
NM_009024
Retinoic acid receptor, alpha
Rara
0.759
0.04
NM_008659
Myosin IC
Myo1c
−0.818
0.00
NM_001002239
Ribosomal protein L17, mRNA
Rpl17
−0.85
0.02
NM_146011
Rho GTPase activating protein 9
Arhgap9
−0.872
0.01
NM_020261
Pregnancy-specific glycoprotein 23
Psg23
−0.874
0.01
NM_016892
Copper chaperone for superoxide dismutase
Ccs
−0.905
0.02
NM_021469
Dysferlin
Dysf
−0.943
0.04
NM_027015
Ribosomal protein S27
Rps27
−1.174
0.02
NM_010826
MRV integration site 1
Mrvi1
−1.218
0.01
NM_007913
Early growth response 1
Egr1
−1.423
0.01
NM_017398
Diaphanous homolog 2 (Drosophila)
Diap2
−1.485
0.04
(b)
RefSeq
Description
Gene symbol
Log2 fold change
value
NM_025557
Purkinje cell protein 4-like 1
Pcp4l1
1.988
0.01
NM_008250
H2.0-like homeo box 1 (Drosophila)
Hlx1
1.544
0.05
NM_013549
Histone cluster 2, H3c2
Hist2h3c2
1.536
0.01
NM_011620
Troponin T3, skeletal, fast
Tnnt3
1.426
0.04
NM_029688
Sulfiredoxin 1 homolog (S. cerevisiae)
Srxn1
1.335
0.03
NM_026095
Small nuclear ribonucleoprotein D3
Snrpd3
1.277
0.04
NM_010382
Histocompatibility 2, class II antigen E beta
H2-Eb1
1.264
0.02
NM_008162
Glutathione peroxidase 4
Gpx4
1.221
0.02
XM_488375
Similar to barrier to autointegration factor 1 (LOC385407)
—
1.215
0.02
NM_007507
ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e
Atp5k
1.199
0.01
NM_011313
S100 calcium-binding protein A6 (calcyclin)
S100a6
1.197
0.02
XM_128110
Polymerase (RNA) II (DNA directed) polypeptide F
Polr2f
1.195
0.00
NM_207648
Histocompatibility 2, Q region locus 6
H2-Q6
1.176
0.01
NM_010361
Glutathione S-transferase, theta 2
Gstt2
1.166
0.01
NM_181316
RIKEN cDNA E130103I17 gene
E130103I17Rik
1.136
0.03
NM_011119
Proliferation-associated 2G4
Pa2g4
1.119
0.03
NM_153152
RIKEN cDNA 2410015M20 gene
2410015M20Rik
1.086
0.01
NM_053078
DNA segment, human D4S114 (D0H4S114), transcript variant 1
—
1.065
0.04
NM_013706
CD52 antigen
Cd52
1.047
0.02
NM_026616
Ribonuclease H2, subunit C
Rnaseh2c
1.044
0.01
NM_011289
Ribosomal protein L27
Rpl27
1.02
0.01
XM_109683
RIKEN cDNA 1810027O10 gene
1810027O10Rik
1.006
0.02
NM_018832
PDZ domain containing, X chromosome
Pdzx
1.003
0.02
NM_024171
Sec61 beta subunit
Sec61b
0.95
0.02
NM_009081
Ribosomal protein L28
Rpl28
0.95
0.04
NM_008210
H3 histone, family 3A
H3f3a
0.942
0.02
XM_193800
RIKEN cDNA 1500032L24 gene
1500032L24Rik
0.927
0.01
XM_489638
Ribosomal protein L26
Rpl26
0.91
0.04
NM_021407
Triggering receptor expressed on myeloid cells 3
Trem3
0.872
0.02
NM_009811
Caspase 6
Casp6
0.858
0.04
NM_011185
Proteasome (prosome, macropain) subunit, beta type 1
Psmb1
0.855
0.01
NM_008303
Heat shock protein 1 (chaperonin 10), related sequence 1