NucVoter: A Voting Algorithm for Reliable Nucleosome Prediction Using Next-Generation Sequencing Data

<table>Nucleosome prediction process. (a) Nucleosomes connected by linker DNA. (b) Nucleosomes following MNase digestion. (c) Purified DNA fragments. Arrowed marks indicate the 5′ ends, which are sequenced via NGS. (d) Short sequence tags generated by NGS. (e) Distribution of tags mapped to the reference genome. F and R indicate the forward and reverse strands, respectively. (f) Tag smoothing and nucleosome prediction. Ellipses represent predicted nucleosomes. (g) Example of tag distributions, which are not well separated.</table>

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Figure 3: NucVoter: A Voting Algorithm for Reliable Nucleosome Prediction Using Next-Generation Sequencing Data 