Table of Contents
ISRN Genetics
Volume 2013 (2013), Article ID 184063, 6 pages
http://dx.doi.org/10.5402/2013/184063
Review Article

Functional Interactions in Transcription and Splicing of Ewing’s Sarcoma

Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Street Building 21, 1113 Sofia, Bulgaria

Received 27 May 2013; Accepted 1 July 2013

Academic Editors: M. Stemmler and A. Yamamoto

Copyright © 2013 Roumiana Todorova. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ewing’s sarcoma (EWS) protein is a member of the TET (TLS/EWS/TAF15) family of RNA and DNA-binding proteins with unknown cellular role. EWS protein is encoded by the EWS oncogene on chromosome 22q12, a target of chromosomal translocations in Ewing’s sarcoma tumors. The exact mechanism of EWS participation in gene expression and pathogenesis of the resulting cancers is not defined. The binding partners of native EWS and EWS fusion proteins (EFPs) are described schematically in a model, an attempt to link the transcription with the splicing. The experimental data about the partnerships of EWS and EFPs are summarized, which may lead to better understanding of their function.