Table of Contents
ISRN Nephrology
Volume 2013 (2013), Article ID 185989, 5 pages
Clinical Study

Dialysis Efficiency of AN69, a Semisynthetic Membrane Not Well Suited for Diffusion

1ICU, Carlos Haya Hospital, Carlos Haya Avenue s/n, 29010 Málaga, Spain
2Nephrology, Carlos Haya Hospital, 29010 Málaga, Spain

Received 3 October 2012; Accepted 14 November 2012

Academic Editors: D. G. Struijk and A. Tzamaloukas

Copyright © 2013 M. E. Herrera-Gutiérrez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


AN69 membrane is not suited for diffusion, with an suggested limit at 25 mL/min dialysate flow rate. When prescribing continuous hemodialysis this threshold must be surpassed to achieve. We designed a study aimed to check if a higher dose of dialysis could be delivered efficiently with this membrane. Ten ICU patients under continuous hemodiafiltration with 1.4 m2 AN69 membrane were included and once a day we set the monitor to exclusively 50 mL/min dialysate flow rate and 250 mL/min blood flow rate and after 15 minutes measured dialysate saturation for urea, creatinine, and -microglobulin. We detected that urea saturation of dialysate was nearly complete ( ) for at least 40 hours, while creatinine saturation showed a large dispersion ( ) and did not detect any relation for these variables with time, blood flow, or anticoagulation regime. Saturation of -microglobulin was low ( ) and decreased discretely with time ( , ) and significantly with TMP increases ( , ). In our experience AN69 membrane shows a better diffusive capability than previously acknowledged, covering efficiently the range of standard dosage for continuous therapies. Creatinine is not a good marker of the membrane diffusive capability.