The Role of Interleukin-1 Genotype in the Association between Coronary Heart Disease and Periodontitis in a Syrian Population

Table 5

IL-1 genotypes of subjects with and without CHD by varying degrees of ABL.

	Alveolar bone loss
Genotype frequency	Mild		Moderate		Severe		P value
	𝑛	%	𝑛	%	𝑛	%
IL-1α +4845
CHD
1.1	7	88%	31	78%	26	50%	0.009
Combination 1.2 + 2.2	1	12%	9	22%	26	50%
Non-CHD
1.1	12	100%	18	32%	7	22%	<0.001
Combination 1.2 + 2.2	0	0%	38	68%	25	78%
IL-1𝛽 +3954
CHD
1.1	5	63%	27	68%	23	44%	0.070
Combination 1.2 + 2.2	3	37%	13	32%	29	56%
Non-CHD
1.1	9	75%	30	54%	13	41%	0.133
Combination 1.2 + 2.2	3	25%	26	46%	19	59%
IL-1𝛽  −511
CHD
1.1	5	63%	9	23%	29	56%	0.003
Combination 1.2 + 2.2	3	37%	31	77%	23	44%
Non-CHD
1.1	8	33%	32	29%	40	63%	<0.001
Combination 1.2 + 2.2	16	67%	80	71%	24	37%
IL-1 RA VNTR
CHD
1.1	5	63%	14	35%	27	52%	0.107
Combination 1.2 + 2.2	3	37%	26	65%	25	48%
Non-CHD
1.1	4	33%	30	54%	23	72%	0.054
Combination 1.2 + 2.2	8	67%	26	46%	9	28%