Table of Contents
ISRN Physical Chemistry
Volume 2013, Article ID 202781, 12 pages
Research Article

An Approximate Analytical Method for the Evaluation of the Concentrations and Current for Hybrid Enzyme Biosensor

Department of Mathematics, The Madura College, Madurai 625011, Tamil Nadu, India

Received 22 November 2012; Accepted 13 December 2012

Academic Editors: I. Anusiewicz, H. Reis, and H. Saint-Martin

Copyright © 2013 Indira Krishnaperumal and Rajendran Lakshmanan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mathematical modeling of amperometric biosensor with cyclic reaction is discussed. Analytical expressions pertaining to the concentration of substrate, cosubstrate, reducing agent and medial product and current for hybrid enzyme biosensor are obtained in terms of Thiele module and saturation parameters. In this paper, a powerful analytical method, called homotopy analysis method (HAM) is used to solve the system of nonlinear differential equations. Furthermore, in this work the numerical simulation of the problem is also reported using Scilab/Matlab program. Our analytical results are compared with simulation results. A good agreement between analytical and numerical results is noted.