Table of Contents
ISRN Nutrition
Volume 2013, Article ID 209360, 6 pages
http://dx.doi.org/10.5402/2013/209360
Research Article

Intake of n-3 Polyunsaturated Fatty Acids Increases Omega-3 Index in Aged Male and Female Spontaneously Hypertensive Rats

1Institute for Heart Research, Slovak Academy of Sciences, Dúbravská Cesta 9, P.O. Box 104, 840 05 Bratislava, Slovakia
2Institute of Animal Biochemistry and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia
3Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia

Received 30 November 2012; Accepted 8 January 2013

Academic Editors: M. S. Buchowski, M. V. Catani, J. Jeon, and D. Mauricio

Copyright © 2013 Barbara Bačová et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. K. A. Witte and A. L. Clark, “Marine polyunsaturated fatty acids in heart failure are the theoretical benefits matched by the clinical data?” Polskie Archiwum Medycyny Wewnetrznej, vol. 119, no. 3, pp. 162–169, 2009. View at Google Scholar · View at Scopus
  2. S. J. Coker, J. R. Parratt, M. I. Ledingham, and I. J. Zeitlin, “Evidence that thromboxane contributes to ventricular fibrillation induced by reperfusion of the ischaemic myocardium,” Journal of Molecular and Cellular Cardiology, vol. 14, no. 8, pp. 483–485, 1982. View at Google Scholar · View at Scopus
  3. B. London, C. Albert, M. E. Anderson et al., “Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research—a report from the national heart, lung, and blood institute and office of dietary supplements omega-3 fatty acids and their role in cardiac arrhythmogenesis workshop,” Circulation, vol. 116, no. 10, pp. e320–e335, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Rupp, T. P. Rupp, P. Alter, and B. Maisch, “Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in ‘HUFA deficiency’,” Canadian Journal of Physiology and Pharmacology, vol. 90, no. 1, pp. 55–73, 2012. View at Publisher · View at Google Scholar
  5. M. Mitasíková, S. Smidová, A. Macsaliová et al., “Aged male and female spontaneously hypertensive rats benefit from n-3 polyunsaturated fatty acids supplementation,” Physiological Research, vol. 57, supplement 2, pp. S39–S48, 2008. View at Google Scholar · View at Scopus
  6. S. S. D. Nair, J. W. Leitch, J. Falconer, and M. L. Garg, “Prevention of cardiac arrhythmia by dietary (n-3) polyunsaturated fatty acids and their mechanism of action,” Journal of Nutrition, vol. 127, no. 3, pp. 383–393, 1997. View at Google Scholar · View at Scopus
  7. C. von Schacky and W. S. Harris, “Cardiovascular risk and the omega-3 index,” Journal of Cardiovascular Medicine, vol. 8, supplement 1, pp. S46–S49, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. W. S. Harris and C. von Schacky, “The omega-3 index: a new risk factor for death from coronary heart disease?” Preventive Medicine, vol. 39, no. 1, pp. 212–220, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Radosinska, B. Bacova, I. Bernatova et al., “Myocardial NOS activity and connexin-43 expression in untreated and omega-3 fatty acids-treated spontaneously hypertensive and hereditary hypertriglyceridemic rats,” Molecular and Cellular Biochemistry, vol. 347, no. 1-2, pp. 163–173, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Radosinska, B. Bacova, B. Benova, V. Knezl, J. Slezak, and N. Tribulova, “Young and old hypertensive rats benefit from omega-3 fatty acids due to attenuation of myocardial abnormalities in intercellular signaling and supression of malignant arrhythmias,” Kidney and Blood Pressure Research, vol. 35, pp. 89–105, 2011. View at Google Scholar
  11. S. K. Sukrutha, Z. Adamechova, R. B. Kunder, J. Savitha, and M. Certik, “Endophytic fungi: are they potential candidates for the production of polyunsaturated fatty acids?” International Journal of Applied Microbiology Sciences, vol. 1, no. 2, pp. 44–49, 2012. View at Google Scholar
  12. C. E. Childs, S. P. Hoile, G. C. Burdge, and P. C. Calder, “Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression,” Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 86, no. 4, pp. 141–147, 2012. View at Publisher · View at Google Scholar
  13. F. Gao, A. Y. Taha, K. Ma, L. Chang, D. Kiesewetter, and S. I. Rapoport, “Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver,” AGE, 2012. View at Publisher · View at Google Scholar
  14. C. E. Childs, T. Romijn, U. Enke, S. Hoile, and P. C. Calder, “Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 83, no. 4–6, pp. 179–184, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Tranchida, L. Tchiakpe, Z. Rakotoniaina, V. Deyris, O. Ravion, and A. Hiol, “Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats,” Journal of Zhejiang University Science B, vol. 13, no. 4, pp. 307–317, 2012. View at Publisher · View at Google Scholar
  16. A. Y. Taha, M. Basselin, E. Ramadan, H. R. Modi, S. I. Rapoport, and Y. Cheon, “Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats,” Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 87, no. 4, pp. 91–101, 2012. View at Publisher · View at Google Scholar
  17. S. Zeghichi-Hamri, M. de Lorgeril, P. Salen et al., “Protective effect of dietary n-3 polyunsaturated fatty acids on myocardial resistance to ischemia-reperfusion injury in rats,” Nutrition Research, vol. 30, no. 12, pp. 849–857, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. W. S. Harris, “Linoleic acid and coronary heart disease,” Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 79, no. 3, pp. 169–171, 2008. View at Publisher · View at Google Scholar
  19. T. L. Blasbalg, J. R. Hibbeln, C. E. Ramsden, S. F. Majchrzak, and R. R. Rawlings, “Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century,” American Journal of Clinical Nutrition, vol. 93, no. 5, pp. 950–962, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. R. A. Gibson, M. A. Neumann, E. L. Lien, K. A. Boyd, and W. C. Tu, “Docosahexaenoic acid synthesis from α-linolenic acid is inhibited by diets high in polyunsaturated fatty acids,” Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 88, no. 1, pp. 139–146, 2013. View at Publisher · View at Google Scholar
  21. C. V. Anselmi, C. Ferreri, V. Novelli et al., “Fatty acid percentage in erythrocyte membranes of atrial flutter/fibrillation patients and controls,” Journal of Interventional Cardiac Electrophysiology, vol. 27, no. 2, pp. 95–99, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. R. DeCaterina, D. Giannessi, A. Mazzone et al., “Vascular prostacyclin is increased in patients ingesting ω-3 polyunsaturated fatty acids before coronary artery bypass graft surgery,” Circulation, vol. 82, no. 2, pp. 428–438, 1990. View at Google Scholar · View at Scopus
  23. M. H. M. Yousif and I. F. Benter, “Role of 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of vascular function in a model of hypertension and endothelial dysfunction,” Pharmacology, vol. 86, no. 3, pp. 149–156, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Pearson, A. Y. Warren, D. A. Barrett, and R. N. Khan, “Detection of EETs and HETE-generating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function,” American Journal of Physiology, vol. 297, no. 3, pp. E647–E656, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. W. K. Lin, J. R. Falck, and P. Y. K. Wong, “Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats,” Biochemical and Biophysical Research Communications, vol. 167, no. 3, pp. 977–981, 1990. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Jiang, J. Quilley, A. B. Doumad et al., “Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats,” American Journal of Physiology, vol. 300, no. 6, pp. H1990–H1996, 2011. View at Publisher · View at Google Scholar
  27. R. Farzaneh-Far, W. S. Harris, S. Garg, B. Na, and M. A. Whooley, “Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: the heart and soul study,” Atherosclerosis, vol. 205, no. 2, pp. 538–543, 2009. View at Publisher · View at Google Scholar · View at Scopus