Spectrophotometric Determination of Some Non-Sedating Antihistamines Using Erythrosine B

Table 2

Spectral characteristics for the reaction of the studied drugs with erythrosine B^a.

Parameter	CTZ	EBS	FXD	KET	LOR
𝜆max (nm)	550	550	550	550	550
Linearity range (μg/mL)	1–7	1–8	1–8	1–7	1–6
(𝑟) ± SD*	0.9996±6.3×10^−4	0.9997±1.4×10^−4	0.9998±2.2×10^−4	0.9996±2.3×10^−4	0.9998±1.7×10^−4
𝑅^2 ± SD*	0.9992±1.2×10^−3	0.9994±2.8×10^−4	0.9996±2.5×10^−5	0.9992±4.3×10^−4	0.9996±3.9×10^−4
Intercept (a) ± SD*	−0.084±5.1×10^−3	−0.118±1.1×10^−2	−0.093±6.2×10^−3	−0.098±1.0×10^−3	−0.119±1.1×10^−2
Slope (b) ± SD*	0.131±1.1×10^−3	0.143±3.7×10^−3	0.150±1.4×10^−3	0.157±1.7×10^−3	0.188±6.4×10^−3
LOD^b (μg/mL)	0.13	0.25	0.14	0.21	0.19
LOQ^c (μg/mL)	0.39	0.77	0.41	0.64	0.58

aAverage of six replicates.
^bLimit of detection.
^cLimit of quantitation.
*Standard deviation.