Predictors of Disseminated Intravascular Coagulation in Patients with Septic Shock
Table 1
Baseline demographics, physiologic and laboratory values at the time of diagnosis of septic shock and early goal-directed therapy, and interventions assessment.
No DIC 324 (83%)
DIC 66 (17%)
value
Baseline Demographics
Age, years, median (IQR)
69 (57–80)
63 (54–74)
0.01
Male gender, (%)
173 (53)
37 (56)
0.78
Caucasian, (%)
295 (91)
55 (83)
0.07
Coronary artery disease, (%)
97 (30)
19 (29)
0.68
Cerebrovascular disease, (%)
44 (14)
8 (12)
0.78
Hypertension, (%)
182 (56)
35 (53)
0.68
Diabetes mellitus, (%)
94 (29)
17 (26)
0.65
End-stage renal disease, (%)
25 (8)
7 (11)
0.45
Congestive heart failure, (%)
99 (31)
13 (20)
0.09
Positive blood cultures, (%)
54 (17)
22 (33)
0.003
Medications
Antiplatelet therapy, (%)
135 (42)
10 (15)
<0.001
Clopidogrel, (%)
35 (11)
2 (3)
0.06
Aspirin, (%)
114 (35)
9 (14)
<0.001
Warfarin, (%)
22 (7)
4 (6)
0.99
Prophylactic subcutaneous heparin, (%)
137 (42)
19 (29)
0.04
Chronic steroid use, (%)
63 (19)
12 (18)
0.99
Physiologic Markers
Acute physiology score, median (IQR)
68 (50–85)
84 (66–120)
<0.001
APACHE III, median (IQR)
84 (67–102)
96 (79–135)
<0.001
CV SOFA, median (IQR)
3 (3-4)
4 (3-4)
0.001
Predicted hospital death, % median (IQR)
37 (19–62)
58 (31–80)
<0.001
MAP mmHg, median (IQR)
56 (51–60)
55 (49–60)
0.31
Heart rate bpm, median (IQR)
97 (80–111)
103 (88–117)
0.02
Respiratory rate, median (IQR)
21 (18–26)
22 (19–27)
0.38
Laboratory Values
Lactate mg/dL, median (IQR)
1.8 (1–1.31)
2.9 (1.5–5.9)
<0.001
Bicarbonate mmol/L, median (IQR)
20 (17–25)
17 (13–21)
<0.001
Platelet count per mm3, median (IQR)
225 (158–310)
197 (148–284)
0.08
WBC count per mm3, median (IQR)
13.7 (9.3–20)
12 (6.4–22)
0.14
EGDT Assessment
Adequate resuscitation
177 (57)
12 (18)
<0.001
Time to adequate empiric antibiotics hours, median (IQR)
