International Scholarly Research Notices / 2013 / Article / Tab 1

Research Article

Predictors of Disseminated Intravascular Coagulation in Patients with Septic Shock

Table 1

Baseline demographics, physiologic and laboratory values at the time of diagnosis of septic shock and early goal-directed therapy, and interventions assessment.

No DIC
324 (83%)
DIC
66 (17%)
value

Baseline Demographics
Age, years, median (IQR)69 (57–80)63 (54–74)0.01
Male gender, (%)173 (53)37 (56)0.78
Caucasian, (%)295 (91)55 (83)0.07
Coronary artery disease, (%)97 (30)19 (29)0.68
Cerebrovascular disease, (%)44 (14)8 (12)0.78
Hypertension, (%)182 (56)35 (53)0.68
Diabetes mellitus, (%)94 (29)17 (26)0.65
End-stage renal disease, (%)25 (8)7 (11)0.45
Congestive heart failure, (%)99 (31)13 (20)0.09
Positive blood cultures, (%)54 (17)22 (33)0.003
Medications
Antiplatelet therapy, (%)135 (42)10 (15)<0.001
Clopidogrel, (%)35 (11)2 (3)0.06
Aspirin, (%)114 (35)9 (14)<0.001
Warfarin, (%)22 (7)4 (6)0.99
Prophylactic subcutaneous heparin, (%)137 (42)19 (29)0.04
Chronic steroid use, (%)63 (19)12 (18)0.99
Physiologic Markers
Acute physiology score, median (IQR)68 (50–85)84 (66–120)<0.001
APACHE III, median (IQR)84 (67–102)96 (79–135)<0.001
CV SOFA, median (IQR)3 (3-4)4 (3-4)0.001
Predicted hospital death, % median (IQR)37 (19–62)58 (31–80)<0.001
MAP mmHg, median (IQR)56 (51–60)55 (49–60)0.31
Heart rate bpm, median (IQR)97 (80–111)103 (88–117)0.02
Respiratory rate, median (IQR)21 (18–26)22 (19–27)0.38
Laboratory Values
Lactate mg/dL, median (IQR)1.8 (1–1.31)2.9 (1.5–5.9)<0.001
Bicarbonate mmol/L, median (IQR)20 (17–25)17 (13–21)<0.001
Platelet count per mm3, median (IQR)225 (158–310)197 (148–284)0.08
WBC count per mm3, median (IQR)13.7 (9.3–20)12 (6.4–22)0.14
EGDT Assessment
Adequate resuscitation177 (57)12 (18)<0.001
Time to adequate empiric antibiotics hours, median (IQR)1.3 (0–4)5.6 (1–12)<0.001
Duration of hypotension minutes, median (IQR)15 (11–60)60 (15–120)<0.001
Time to source control hours, median (IQR)11.3 (5–27)21 (5–36)0.44
Steroids, (%)181 (56)55 (83)<0.001
Activated protein C, (%)17 (5.3)9 (13.6)0.02

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