Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis

Figure 1

The “multiple parallel hits” hypothesis for the pathogenesis on NASH and the pathophysiological characteristics of animal models. The intake of a high-fat and high-fructose diet and overnutrition lead to metabolic syndrome and obesity. The progression to steatohepatitis in liver is in a stepwise manner involving first the development of fatty changes and, later, hepatic inflammation. Some of the animal models and pathogenic processes are also summarized.