Tramadol Extended-Release for the Management of Pain due to Osteoarthritis

Table 1

Reported adverse events ranges and discontinuation rates within each tramadol formulation [65].

Adverse event	IR; 200–400 mg/day; (4–6 doses/day)	CR; 100–400 mg/day; (QD)	SR; 100–400 mg/day; (QD or BID)	OAD; 100–400 mg/day; (QD)	ER; 100–400 mg/day; (QD)
Dizziness	6.8–17	5.3–24	8.1–36	9.7–25.6	16.8–33
Somnolence	6.8–28	15–37.2	11.7–21.4	6.7–30.2	8–20.3
Headache	5–18.5	2.1–22	4.5–17.7	<5–12.6	14.4–15.8
Nausea	17.5–53.7	16.2–42.6	22.5–34	11.3–32.6	14.9–25.7
Constipation	3.4–45	17.1–23.8	9.9–30.2	10.2–34	12.9–29.7
Vomiting	5–18.5	4.3–19	14.4–17.1	<5–14.8	5.4–9.4
Discontinuation; Rate due to AEs	4.7–53.7	12.8–36.7	10.2–21.6	8.8–32.4	22.5–26.6

Frequencies of adverse events presentation are expressed as a percentage.