Review Article

Applications of RNA Interference in Schistosomiasis: Gene Function Identification and Development of New Therapies

Figure 1

Diagram depicting the molecular mechanism of gene silencing by RNAi. Inside the cell, the introduced long dsRNA is cleaved by nucleases into small interfering RNAs (siRNAs). SiRNAs are loaded into the RISC complex which promotes the cleavage of target mRNA, thus inducing silencing of the target gene.
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