Table of Contents
ISRN Dermatology
Volume 2013, Article ID 250597, 3 pages
http://dx.doi.org/10.1155/2013/250597
Research Article

Antidermatophytic Properties of Ar-Turmerone, Turmeric Oil, and Curcuma longa Preparations

1Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudthaya Road, Ratchathewi, Bangkok 10400, Thailand
2Department of Microbiology, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudthaya Road, Ratchathewi, Bangkok 10400, Thailand

Received 28 May 2013; Accepted 28 July 2013

Academic Editors: M. Ericson, E. Pasmatzi, and K. Saga

Copyright © 2013 Mukda Jankasem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Curcuma longa L. or turmeric of the family Zingiberaceae is widely used in Thai traditional medicines for the treatment of rash, itching, tinea, and ringworm. Previous studies on turmeric oil reported effective antifungal activity against dermatophytes, a group of fungi that causes skin diseases. In this study, turmeric creams containing 6 and 10% w/w turmeric oil were prepared and tested against clinical strains of dermatophytes using broth dilution technique. Minimum fungicidal concentrations of 6 and 10% w/w turmeric creams were found to be 312 μg/mL. Ar-turmerone, a major compound separated from turmeric oil, promoted more effective antidermatophytic activity with the MICs of 1.56–6.25 μg/mL, compared to 3.90–7.81 μg/mL of standard ketoconazole. The results indicated that 6% w/w turmeric oil in the cream was suitable to be formulated as antidermatophytic preparation. Further research should be done on long-term chemical and antifungal stabilities of the preparation.