Table of Contents
ISRN Inorganic Chemistry
Volume 2013 (2013), Article ID 250791, 11 pages
http://dx.doi.org/10.1155/2013/250791
Research Article

Synthesis, Crystal Structure, Antioxidant, Antimicrobial, and Mutagenic Activities and DNA Interaction Studies of Ni(II) Schiff Base 4-Methoxy-3-benzyloxybenzaldehyde Thiosemicarbazide Complexes

1Department of Chemistry, Central College Campus, Bangalore University, Bangalore 560001, India
2Department of Pharmaceutical Technology, Defence Research Laboratory, Tezpur 784001, India
3Department of Fruit and Vegetable Technology, CFTRI, Mysore 570020, India
4Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir CV Raman Avenue, Bangalore 560012, India

Received 31 July 2013; Accepted 18 August 2013

Academic Editors: P. Deplano and K. Dhara

Copyright © 2013 P. R. Chetana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Three new Ni(II) square planar complexes of 4-methoxy-3-benzyloxybenzaldehyde thiosemicarbazide(4m3BTSC) having polypyridyl bases of general formulation [ML2] (1) and [MLB] (2, 3), where L = 4m3BTSC and B is N,N-donor heterocyclic bases, namely, 1,10-phenanthroline (phen, 2), 2,2′-bipyridine (bpy, 3), are synthesized and characterized. The free radical scavenging assay results showed that complex 1 possesses significant activity when compared to complexes 2 and 3. The biological studies showed that the ligand and its complexes exhibited significant and different biological activities and also the prepared compounds are nonmutagenic. They may be potential commercial antioxidants because of their nonmutagenic and nontoxic nature. The DNA interaction of the new complexes is evaluated by absorption, emission, and melting temperature methods, and the results suggested that the binding affinity of the complexes increases with the presence of planar ligand in the molecule. The nickel (II) complexes with planar phenanthroline bases show moderate DNA binding and cleavage ability.