Table of Contents
ISRN Neuroscience
Volume 2013 (2013), Article ID 253093, 9 pages
http://dx.doi.org/10.1155/2013/253093
Research Article

Xanthine Oxidase Does Not Contribute to Apoptosis after Brain Hypoxia-Ischemia in Immature Rabbits

1Division of Pediatric Critical Care Medicine, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA
2Division of Pediatric Critical Care Medicine, Department of Pediatrics, Los Angeles BioMedical Research Institute, Torrance, CA 90502, USA
3Division of Pediatric Critical Care Medicine, Department of Pediatrics, Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute, David Geffen School of Medicine at UCLA, Torrance, CA 90502, USA

Received 5 June 2013; Accepted 11 July 2013

Academic Editors: A. Unal and A. Witting

Copyright © 2013 Anthony Moretti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. N. Granger, M. E. Hollwarth, and D. A. Parks, “Ischemia-reperfusion injury: role of oxygen-derived free radicals,” Acta Physiologica Scandinavica, vol. 126, supplement 548, pp. 47–63, 1986. View at Google Scholar · View at Scopus
  2. P. Pasdois, J. E. Parker, E. J. Griffiths, and A. P. Halestrap, “The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia,” Biochemical Journal, vol. 436, no. 2, pp. 493–505, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Cherin, M. Catbagan, S. Treiman, and R. Mink, “The effect of normothermic and hypothermic hypoxia-ischemia on brain hypoxanthine phosphoribosyl transferase activity,” Neurological Research, vol. 28, no. 8, pp. 831–836, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. T. D. Engerson, G. McKelvey, and D. B. Rhyne, “Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues,” Journal of Clinical Investigation, vol. 79, no. 6, pp. 1564–1570, 1987. View at Google Scholar · View at Scopus
  5. A. Valencia and J. Morán, “Reactive oxygen species induce different cell death mechanisms in cultured neurons,” Free Radical Biology and Medicine, vol. 36, no. 9, pp. 1112–1125, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Itoh, M. Kawakami, and Y. Yamauchi, “Effect of allopurinol on ischemia and reperfusion-induced cerebral injury in spontaneously hypertensive rats,” Stroke, vol. 17, no. 6, pp. 1284–1287, 1986. View at Google Scholar · View at Scopus
  7. D. Martz, G. Rayos, G. P. Schielke, and A. L. Betz, “Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats,” Stroke, vol. 20, no. 4, pp. 488–494, 1989. View at Google Scholar · View at Scopus
  8. R. Mink and J. Johnston, “The effect of infusing hypoxanthine or xanthine on hypoxic-ischemic brain injury in rabbits,” Brain Research, vol. 1147, no. 1, pp. 256–264, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. R. B. Mink, A. J. Dutka, and J. M. Hallenbeck, “Allopurinol pretreatment improves evoked response recovery following global cerebral ischemia in dogs,” Stroke, vol. 22, no. 5, pp. 660–665, 1991. View at Google Scholar · View at Scopus
  10. R. B. Mink, A. J. Dutka, K. K. Kumaroo, and J. M. Hallenbeck, “No conversion of xanthine dehydrogenase to oxidase in canine cerebral ischemia,” American Journal of Physiology, vol. 259, no. 6, pp. H1655–H1659, 1990. View at Google Scholar · View at Scopus
  11. L. S. Terada, J. D. Rubinstein, E. J. Lesnefsky, L. D. Horwitz, J. A. Leff, and J. E. Repine, “Existence and participation of xanthine oxidase in reperfusion injury of ischemic rabbit myocardium,” American Journal of Physiology, vol. 260, no. 3, pp. H805–H810, 1991. View at Google Scholar · View at Scopus
  12. B. W. Böttiger, B. Schmitz, C. Wiessner, P. Vogel, and K. Hossmann, “Neuronal stress response and neuronal cell damage after cardiocirculatory arrest in rats,” Journal of Cerebral Blood Flow and Metabolism, vol. 18, no. 10, pp. 1077–1087, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. O. P. Mishra and M. Delivoria-Papadopoulos, “Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets,” Neuroscience Letters, vol. 401, no. 1-2, pp. 81–85, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. J. M. McCord, “Oxygen-derived free radicals in postischemic tissue injury,” New England Journal of Medicine, vol. 312, no. 3, pp. 159–163, 1985. View at Google Scholar · View at Scopus
  15. A. Sola, V. Alfaro, and G. Hotter, “Intestinal ischemic preconditioning: less xanthine accumulation relates with less apoptosis,” Apoptosis, vol. 9, no. 3, pp. 353–361, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Cheng, M. Deshumukh, A. D. Costa et al., “Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury,” Journal of Clinical Investigation, vol. 101, pp. 1992–1999, 1998. View at Google Scholar
  17. K. A. Elliott and H. H. Jasper, “Physiological salt solutions for brain surgery; studies of local pH and,” Journal of Neurosurgery, vol. 6, no. 2, pp. 140–152, 1949. View at Google Scholar · View at Scopus
  18. S. Treiman, M. Catbagan, C. Hatchette, T. Cherin, and R. Mink, “Administration of allopurinol and hypoxanthine improves recovery of adenine nucleotides after cerebral hypoxia-ischemia in rabbits,” Critical Care Medicine, vol. 31, no. 2, p. A24, 2002. View at Google Scholar
  19. C. Peeters-Scholte, K. Braun, J. Koster et al., “Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia,” Pediatric Research, vol. 54, no. 4, pp. 516–522, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Bågenholm, U. A. Nilsson, C. W. Götborg, and I. Kjellmer, “Free radicals are formed in the brain of fetal sheep during reperfusion after cerebral ischemia,” Pediatric Research, vol. 43, no. 2, pp. 271–275, 1998. View at Google Scholar · View at Scopus
  21. H. A. Kontos, “Oxygen radicals in cerebral ischemia: the 2001 Willis lecture,” Stroke, vol. 32, no. 11, pp. 2712–2716, 2001. View at Google Scholar · View at Scopus
  22. B. Herrera, M. M. Murillo, A. Álvarez-Barrientos, J. Beltrán, M. Fernández, and I. Fabregat, “Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-β in fetal rat hepatocytes,” Free Radical Biology and Medicine, vol. 36, no. 1, pp. 16–26, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Khurana, Q. M. Ashraf, O. P. Mishra, and M. Delivoria-Papadopoulos, “Effect of hypoxia on caspase-3, -8, and -9 activity and expression in the cerebral cortex of newborn piglets,” Neurochemical Research, vol. 27, no. 9, pp. 931–938, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Pirzadeh, A. Mammen, J. Kubin et al., “Early regional response of apoptotic activity in newborn piglet brain following hypoxia and ischemia,” Neurochemical Research, vol. 36, no. 1, pp. 83–92, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Tamta, S. Kalra, and A. K. Mukhopadhyay, “Biochemical characterization of some pyrazolopyrimidine-based inhibitors of xanthine oxidase,” Biochemistry, vol. 71, supplement 1, pp. S49–S54, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Y. Wang, S. C. Sorice, and R. B. Mink, “The effect of allopurinol on guanine-based purine metabolism after cerebral hypoxia-ischemia in rabbits,” Critical Care Medicine, vol. 34, p. A37, 2006. View at Google Scholar
  27. S. Pirouzpanah, J. Hanaee, S. Razavieh, and M. Rashidi, “Inhibitory effects of flavonoids on aldehyde oxidase activity,” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 24, no. 1, pp. 14–21, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Joly, V. Mucignat, J. Mariani, M. Plotkine, and C. Charriaut-Marlangue, “Caspase inhibition after neonatal ischemia in the rat brain,” Journal of Cerebral Blood Flow and Metabolism, vol. 24, no. 1, pp. 124–131, 2004. View at Google Scholar · View at Scopus