The Role of Neurotransmitters in Protection against Amyloid-β Toxicity by KiSS-1 Overexpression in SH-SY5Y Neurons
Figure 6
Effect of adrenergic receptor antagonism on KiSS-1 gene overexpression neuroprotection against amyloid-β toxicity. PKiSS cells were pretreated with (a) α-adrenergic antagonist phenoxybenzamine hydrochloride (PHB: 10 μM), (b) α-adrenergic antagonist prazosin hydrochloride (PR: 250 nM), (c) α-adrenergic antagonist yohimbine hydrochloride (YO: 50 nM), (d) β-adrenergic antagonist propranolol hydrochloride (PROP: 50 nM) for 2 h prior to exposure to Aβ 1–40 (10 μM) and determination of viability by MTT reduction. Results are mean ± s.e.m. * versus control (media alone); † versus Aβ alone; one-way ANOVA.
