Table of Contents
ISRN Oxidative Medicine
Volume 2013, Article ID 257463, 7 pages
http://dx.doi.org/10.1155/2013/257463
Research Article

Beneficial Regulation of Elastase Activity and Expression of Tissue Inhibitors of Matrixmetalloproteinases, Fibrillin, Transforming Growth Factor- , and Heat Shock Proteins by P. leucotomos in Nonirradiated or Ultraviolet-Radiated Epidermal Keratinocytes

1School of Natural Sciences, Fairleigh Dickinson University, 1000 River Road, Teaneck, NJ 07666, USA
2Memorial Sloan-Kettering Cancer Center, 1275 York Ave, NY 10065, USA

Received 19 August 2013; Accepted 21 October 2013

Academic Editors: A. B. Salmon, T. B. Shea, A. Shukla, and Y. Yoshida

Copyright © 2013 Neena Philips and Salvador Gonzalez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Gombau, F. García, A. Lahoz et al., “Polypodium leucotomos extract: antioxidant activity and disposition,” Toxicology in Vitro, vol. 20, no. 4, pp. 464–471, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Philips, J. Smith, T. Keller, and S. Gonzalez, “Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes,” Journal of Dermatological Science, vol. 32, no. 1, pp. 1–9, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Philips, J. Conte, Y.-J. Chen et al., “Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-β by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells,” Archives of Dermatological Research, vol. 301, no. 7, pp. 487–495, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. R. E. B. Watson, C. E. M. Griffiths, N. M. Craven, C. A. Shuttleworth, and C. M. Kielty, “Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction,” Journal of Investigative Dermatology, vol. 112, no. 5, pp. 782–787, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. R. E. B. Watson, N. M. Craven, S. Kang, C. J. P. Jones, C. M. Kielty, and C. E. M. Griffiths, “A short-term screening protocol, using fibrillin-1 as a reporter molecule, for photoaging repair agents,” Journal of Investigative Dermatology, vol. 116, no. 5, pp. 672–678, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. R. E. Watson, S. Ogden, L. F. Cotterell et al., “Effects of a cosmetic “anti-ageing” product improves photoaged skin [corrected],” The British Journal of Dermatology, vol. 161, no. 2, pp. 419–426, 2009. View at Google Scholar · View at Scopus
  7. N. Philips, T. Keller, and S. Gonzalez, “TGF β-like regulation of matrix metalloproteinases by anti-transforming growth factor-β, and anti-transforming growth factor-β1 antibodies in dermal fibroblasts: implications for wound healing,” Wound Repair and Regeneration, vol. 12, no. 1, pp. 53–59, 2004. View at Google Scholar · View at Scopus
  8. N. Philips and N. Onwubalili, “Anti transforming growth factor-beta (TGF-β) increases the expressions of matrix metalloproteinase-1 (MMP-1) and growth factors in a renal adenocarcinoma cell line,” BIOS, vol. 73, pp. 86–90, 2002. View at Google Scholar
  9. G. Zeng, H. M. McCue, L. Mastrangelo, and A. J. T. Millis, “Endogenous TGF-β activity is modified during cellular aging: Effects on metalloproteinase and TIMP-1 expression,” Experimental Cell Research, vol. 228, no. 2, pp. 271–276, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Philips, R. Arena, and S. Yarlagadda, “Inhibition of ultraviolet radiation mediated extracellular matrix remodeling in fibroblasts by transforming growth factor-b,” BIOS, vol. 80, article 1, 2009. View at Google Scholar
  11. N. Philips, “An anti TGF-β antibody increased the expression of transforming growth factor-β, matrix metalloproteinase-1, and elastin, and its effects were antagonized by ultraviolet radiation in epidermal keratinocytes,” Journal of Dermatological Science, vol. 33, no. 3, pp. 177–179, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Jonak, M. Mildner, G. Klosner et al., “The hsp27kD heat shock protein and p38-MAPK signaling are required for regular epidermal differentiation,” Journal of Dermatological Science, vol. 61, no. 1, pp. 32–37, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Matsuda, T. Hoshino, Y. Yamashita et al., “Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70,” Journal of Biological Chemistry, vol. 285, no. 8, pp. 5848–5858, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Gutsmann-Conrad, A. R. Heydari, S. You, and A. Richardson, “The expression of heat shock protein 70 decreases with cellular senescence in vitro and in cells derived from young and old human subjects,” Experimental Cell Research, vol. 241, no. 2, pp. 404–413, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Rijken, R. C. M. Kiekens, and P. L. B. Bruijnzeel, “Skin-infiltrating neutrophils following exposure to solar-simulated radiation could play an important role in photoageing of human skin,” British Journal of Dermatology, vol. 152, no. 2, pp. 321–328, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Tsuji, S. Moriwaki, Y. Suzuki, Y. Takema, and G. Imokawa, “The role of elastases secreted by fibroblasts in wrinkle formation: implication through selective inhibition of elastase activity,” Photochemistry and Photobiology, vol. 71, pp. 283–290, 2001. View at Google Scholar
  17. J. Labat-Robert, A. Fourtanier, B. Boyer-Lafargue, and L. Robert, “Age dependent increase of elastase type protease activity in mouse skin effect of UV-irradiation,” Journal of Photochemistry and Photobiology B, vol. 57, no. 2-3, pp. 113–118, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Philips, T. Keller, C. Hendrix et al., “Regulation of the extracellular matrix remodeling by lutein in dermal fibroblasts, melanoma cells, and ultraviolet radiation exposed fibroblasts,” Archives of Dermatological Research, vol. 299, no. 8, pp. 373–379, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Zhang, W. Hu, and F. Ramirez, “Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils,” Journal of Cell Biology, vol. 129, no. 4, pp. 1165–1176, 1995. View at Google Scholar · View at Scopus
  20. F. Ramirez and L. Pereira, “The fibrillins,” International Journal of Biochemistry and Cell Biology, vol. 31, no. 2, pp. 255–259, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. H. H. Kim, S. Cho, S. Lee et al., “Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo,” Journal of Lipid Research, vol. 47, no. 5, pp. 921–930, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Philips, L. Dulaj, and T. Upadhya, “Growth inhibitory mechanism of ascorbate and counteraction of its matrix metalloproteinases-1 and transforming growth factor-beta stimulation by gene silencing or P. leucotomos,” AntiCancer Research, vol. 29, pp. 3233–3238, 2008. View at Google Scholar