TY - JOUR
A2 - Crenn, P.
A2 - Nassir, F.
AU - Liu, Ying
AU - Shaw, Ju-Jean
AU - Swaisgood, Harold E.
AU - Allen, Jonathan C.
PY - 2013
DA - 2013/02/19
TI - Bioavailability of Oil-Based and β-Lactoglobulin-Complexed Vitamin A in a Rat Model
SP - 270580
VL - 2013
AB - β-Lactoglobulin is capable of binding fat-soluble compounds including vitamin A palmitate and is suggested to specifically enhance intestinal uptake of retinol. In this study, bioavailability of a vitamin-A-retinyl palmitate complex in skim milk and in water-based liquids was investigated in vitamin-A-depleted rats. First, rats were fed a vitamin-A-free pellet diet for 6 wk and were thereafter gavage-fed with vitamin A in oil, vitamin-A-β-lactoglobulin complex, vitamin A in oil + skim milk, and vitamin-A-β-lactoglobulin + skim milk for 2 wk and 42 wk. Vitamin A repletion, as judged by vitamin A accumulation in serum and liver, occurred in all the treatments. Vitamin-A-β-lactoglobulin complex treatments had statistical equivalence with oil-based vitamin A treatments. In a second experiment, vitamin-A-depleted rats were fed UHT-processed skim milk fortified with either oil-based or freeze-dried β-lactoglobulin-complexed retinyl palmitate. Liver and serum vitamin A were analyzed by HPLC to indicate vitamin A status in the rats. Results showed no significant difference in bioavailability of retinyl palmitate from milk made with either regular oil-based or β-lactoglobulin-complexed fortifiers. The vitamin-A-β-lactoglobulin complex, being water soluble, may be useful for fortification of nonfat products.
SN - null
UR - https://doi.org/10.5402/2013/270580
DO - 10.5402/2013/270580
JF - ISRN Nutrition
PB - Hindawi Publishing Corporation
KW -
ER -