International Scholarly Research Notices / 2013 / Article / Tab 2

Review Article

Platinum and Palladium Polyamine Complexes as Anticancer Agents: The Structural Factor

Table 2

Palladium polyamine complexes developed as anticancer agents.

CompoundNumber of metal centresSuccessful in vitro screening (cell line)Work

aPd(en)(XO)3  
(X = or )
1Murine lymphocytic leukemia
P-388
[281]
bPd(Spd)Cl21Human breast cancer
MDA-MB 468
[169]
bPd3(Spd)Cl63Human breast cancer
MDA-MB 468
[169]
bPd2(Put2)Cl42Human breast cancer/leukemia
MDA-MB 468/HL-60
[170]
bPd(Spm)Cl21Human breast cancer/leukemia
MDA-MB 468/HL-60
[170]
bPd2(Spm)Cl42Human breast cancer/leukemia
MDA-MB 468/HL-60
[170]
c[Pd(en)Cl]2(L)
(L = bpse or bpsu)
2Human ileocecal adenocarcinoma
HCT-8
[95]
cPd(en)(pyr)Cl1Human leukemia
HL-60
[93]
Pd (H2N(CH2)3NH(CH2)3NH2) Cl1[258]
Pd(Spd)Cl1[258]
Pd(Spd)Cl21[258]
Pd2(Spm)Cl42[258]
trans-PtCl(NH3)2][μ-(H2N(CH2)6NH2)   
trans-PdCl(NH3)2
2Human ovarian cancer
A2780, dA2780cisR, and dA2780ZD0473R
[253]
trans-PtCl(NH3)2 2 μ-trans-Pd(NH3)2-
-(H2N NH2)2)2 (n = 4–7)
3Human ovarian cancer
A2780, A2780cisR, and A2780ZD0473R
[254]
trans-PtCl(NH3) 2 μ-trans-Pd(NH3)-
-(2-hydroxypyridine)-(H2N(CH2)6NH2)2
3Human ovarian cancer
A2780, A2780cisR, and A2780ZD0473R
[255]
ePd(dien)(1-MeCyt)1[97]
ePd(dien)(9-EtGH)1[97]
Pd3(Spd2)Cl63Human tongue epithelioma
HSC-3
[165]
Pd2(Spm)Cl42Human tongue epithelioma
HSC-3
[168]
Pd2(Spm)Cl42Human ovarian cancer
A2780 and A2780cisR
[175]
Pd2(Spm)Cl42Human breast cancer
MDA-MB-231 and MCF-7
[180]
fPd3(NSpd2)Cl63[77]
gPd2(BENSpm)Cl42[77]

: ethylenediamine. bPut: putrescine; Spd: spermidine; Spm: spermine. cen: ethylenediamine; bpse: bis(3-methyl-4-pyridyl)selenide; bpsu: bis(3-methyl-4-pyridyl)sulfide; pyr: pyridine. dA2780cisR, A2780ZD0473R: cisplatin- and picoplatin (ZD0473)-resistant cell lines, respectively. edien: diethylenetriamine; 1-MeCyt and 9-EtGH: 1-methylcytosine and 9-ethylguanine nucleobases, respectively. fNSpd: norspermidine, H2N(CH2)3NH(CH2)3NH2. gBENSpm: N1,N11-bis(ethyl)norspermine, (CH3CH2)HN(CH2)3NH(CH2)3NH(CH2)3NH(CH3CH2).