Platinum and Palladium Polyamine Complexes as Anticancer Agents: The Structural Factor

Table 2

Palladium polyamine complexes developed as anticancer agents.

Compound	Number of metal centres	Successful in vitro screening (cell line)	Work
^aPd(en)(XO)3; (X = SeO3^2− or TeO3^2−)	1	Murine lymphocytic leukemia; P-388	[281]
^bPd(Spd)Cl2	1	Human breast cancer; MDA-MB 468	[169]
^bPd3(Spd)Cl6	3	Human breast cancer; MDA-MB 468	[169]
^bPd2(Put2)Cl4	2	Human breast cancer/leukemia; MDA-MB 468/HL-60	[170]
^bPd(Spm)Cl2	1	Human breast cancer/leukemia; MDA-MB 468/HL-60	[170]
^bPd2(Spm)Cl4	2	Human breast cancer/leukemia; MDA-MB 468/HL-60	[170]
^c[Pd(en)Cl]2(L); (L = bpse or bpsu)	2	Human ileocecal adenocarcinoma; HCT-8	[95]
^cPd(en)(pyr)Cl	1	Human leukemia; HL-60	[93]
Pd[(H2N(CH2)3NH(CH2)3NH2)]Cl	1	—	[258]
Pd(Spd)Cl	1	—	[258]
Pd(Spd)Cl2	1	—	[258]
Pd2(Spm)Cl4	2	—	[258]
[trans-PtCl(NH3)2][μ-(H2N(CH2)6NH2)]; [trans-PdCl(NH3)2]	2	Human ovarian cancer; A2780, ^dA2780^cisR, and ^dA2780^ZD0473R	[253]
[trans-PtCl(NH3)2]2[μ-trans-Pd(NH3)2-; -(H2NCH2𝑛NH2)2)2] (n = 4–7)	3	Human ovarian cancer; A2780, A2780^cisR, and A2780^ZD0473R	[254]
[trans-PtCl(NH3)]2[μ-trans-Pd(NH3)-; -(2-hydroxypyridine)-(H2N(CH2)6NH2)2]	3	Human ovarian cancer; A2780, A2780^cisR, and A2780^ZD0473R	[255]
^ePd(dien)(1-MeCyt)	1	—	[97]
^ePd(dien)(9-EtGH)	1	—	[97]
Pd3(Spd2)Cl6	3	Human tongue epithelioma; HSC-3	[165]
Pd2(Spm)Cl4	2	Human tongue epithelioma; HSC-3	[168]
Pd2(Spm)Cl4	2	Human ovarian cancer; A2780 and A2780^cisR	[175]
Pd2(Spm)Cl4	2	Human breast cancer; MDA-MB-231 and MCF-7	[180]
^fPd3(NSpd2)Cl6	3	—	[77]
^gPd2(BENSpm)Cl4	2	—	[77]

^aen: ethylenediamine. ^bPut: putrescine; Spd: spermidine; Spm: spermine. ^cen: ethylenediamine; bpse: bis(3-methyl-4-pyridyl)selenide; bpsu: bis(3-methyl-4-pyridyl)sulfide; pyr: pyridine. ^dA2780^cisR, A2780^ZD0473R: cisplatin- and picoplatin (ZD0473)-resistant cell lines, respectively. ^edien: diethylenetriamine; 1-MeCyt and 9-EtGH: 1-methylcytosine and 9-ethylguanine nucleobases, respectively. ^fNSpd: norspermidine, H₂N(CH₂)₃NH(CH₂)₃NH₂. ^gBENSpm: N₁,N₁₁-bis(ethyl)norspermine, (CH₃CH₂)HN(CH₂)₃NH(CH₂)₃NH(CH₂)₃NH(CH₃CH₂).