Glomerular Disease in Patients with Infectious Processes Developing Antineutrophil Cytoplasmic Antibodies

Table 6

Histological types of glomerular disease, serum complement levels, and ANCA specificity in 50 patients with infections, ANCA positivity, and glomerular disease.

Histological diagnosis	Number of patients	Percent of patients	Low serum complement	c-ANCA and/or PR3	p-ANCA and/or MPO	Other or Nonidentified ANCA
Pauci-immune GN,; vasculitis	23	45	5/10 (38%)	5/23 (22%)	8/23 (35%)	10/23 (43%)
Postinfectious GN	19	38	15/17 (88%)	19/19 (100%)	1/19 (5%)	0
Anti-GMB GN	1	5	0	0	0	1 (100%)
Interstitial nephritis	5	10	4/5 (80%)	2/5 (40%)	3/5 (60%)	0
Acute tubular necrosis	4	8	2/3 (67%)	2/4 (50%)	2/4 (25%)	1/4 (25%)
Other histology^1	2	2	1/1 (100%)	1/2 (50%)	1/2 (50%)
Nonidentified GN^2	7	12	3/3 (100%)	4/7 (57%)	4/7 (57%)	0

GN: glomerulonephritis, GBM: glomerular basement membrane. ¹One each, focal glomerulosclerosis, chronic sclerosing glomerulonephritis. ²Immunofluorescence and electron microscopy findings were not reported. The differentiation between pauci-immune and postinfectious glomerulonephritis was not feasible from only the light microscopy picture.