High-Performance Liquid Chromatographic Method for Analysis of Emtricitabine in Rat Plasma: Method Development, Validation and Application to a Pharmacokinetic Study

Table 3

Pharmacokinetic parameters of emtricitabine at a dose of 15 mg/kg/rat.

Pharmacokinetic parameters	Emtricitabine
𝐶max (µg mL^−1)	1.357 ± 0.029
𝑡max (h)	2.0 ± 0.007
𝑡1/2 (h)	8.153 ± 0.670
AUC0--24 (µg mL^−1 * h)	12.175 ± 0.326
AUMC0--24 (µg mL^−1 * h)	163.51 ± 24.038
𝐾𝑒 (1/h)	0.0681 ± 0.007
MRT	15.6 ± 0.743

Data presented as mean ± standard deviation (𝑛=6).