Table of Contents
ISRN Endocrinology
Volume 2013, Article ID 348705, 7 pages
http://dx.doi.org/10.1155/2013/348705
Clinical Study

Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø

1Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, Norway
2Division of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway
3Division of Surgery and Clinical Neuroscience, Department of Ophthalmology, Oslo University Hospital, 0424 Oslo, Norway

Received 24 January 2013; Accepted 23 February 2013

Academic Editors: C. Bizzarri, O. Giampietro, A. Saxe, and J. Schiettecatte

Copyright © 2013 Rolf Jorde et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. F. Holick, “Medical progress: vitamin D deficiency,” The New England Journal of Medicine, vol. 357, no. 3, pp. 266–281, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. H. F. DeLuca, “Overview of general physiologic features and functions of vitamin D,” American Journal of Clinical Nutrition, vol. 80, no. 6, supplement, pp. 1689S–1696S, 2004. View at Google Scholar
  3. R. Jorde, Y. Figenschau, N. Emaus, M. Hutchinson, and G. Grimnes, “Serum 25-hydroxyvitamin D levels are strongly related to systolic blood pressure but do not predict future hypertension,” Hypertension, vol. 55, no. 3, pp. 792–798, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Jorde, M. Sneve, N. Emaus, Y. Figenschau, and G. Grimnes, “Cross-sectional and longitudinal relation between serum 25-hydroxyvitamin D and body mass index: the Tromsø study,” European Journal of Nutrition, vol. 49, no. 7, pp. 401–407, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Jorde, Y. Figenschau, M. Hutchinson, N. Emaus, and G. Grimnes, “High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile,” European Journal of Clinical Nutrition, vol. 64, no. 12, pp. 1457–1464, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. M. S. Hutchinson, Y. Figenschau, I. Njølstad, H. Schirmer, and R. Jorde, “Serum 25-hydroxyvitamin D levels are inversely associated with glycated haemoglobin (HbA1c). The Tromsø Study,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 71, no. 5, pp. 399–406, 2011. View at Publisher · View at Google Scholar
  7. E. Hyppönen, D. Berry, M. Cortina-Borja, and C. Power, “25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort,” PloS ONE, vol. 5, no. 5, Article ID e10801, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Wang, Y. Song, J. E. Manson et al., “Circulating 25-Hydroxy-Vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies,” Circulation, vol. 5, no. 6, pp. 819–829, 2012. View at Publisher · View at Google Scholar
  9. Y. Ma, P. Zhang, F. Wang, J. Yang, Z. Liu, and H. Qin, “Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies,” Journal of Clinical Oncology, vol. 29, no. 28, pp. 3775–3782, 2011. View at Publisher · View at Google Scholar
  10. A. Zittermann, S. Iodice, S. Pilz, W. B. Grant, V. Bagnardi, and S. Gandini, “Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies,” American Journal of Clinical Nutrition, vol. 95, no. 1, pp. 91–100, 2012. View at Google Scholar
  11. M. S. Hutchinson, G. Grimnes, R. M. Joakimsen, Y. Figenschau, and R. Jorde, “Low serum 25-hydroxyvitamin D levels are associated with increased all-cause mortality risk in a general population: the Tromsø study,” European Journal of Endocrinology, vol. 162, no. 5, pp. 935–942, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Sneve, Y. Figenschau, and R. Jorde, “Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects,” European Journal of Endocrinology, vol. 159, no. 6, pp. 675–684, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Grimnes, Y. Figenschau, B. Almås, and R. Jorde, “Vitamin D, insulin secretion, sensitivity, and lipids: results from a case-control study and a randomized controlled trial using hyperglycemic clamp technique,” Diabetes, vol. 60, no. 11, pp. 2748–2757, 2011. View at Publisher · View at Google Scholar
  14. G. Grimnes, R. Joakimsen, Y. Figenschau, P. A. Torjesen, B. Almås, and R. Jorde, “The effect of high-dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass—a randomized controlled 1-year trial,” Osteoporosis International, vol. 23, no. 1, pp. 201–211, 2012. View at Publisher · View at Google Scholar
  15. M. Kjærgaard, K. Waterloo, C. E. A. Wang et al., “Effect of vitamin D supplement on depression scores in people with low levels of serum 25-hydroxyvitamin D: nested case-control study and randomised clinical trial,” British Journal of Psychiatry, vol. 201, no. 5, pp. 360–368, 2012. View at Publisher · View at Google Scholar
  16. R. Jorde and G. Grimnes, “Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids,” Progress in Lipid Research, vol. 50, no. 4, pp. 303–312, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Wang, N. Xia, Y. Yang, and D.-Q. Peng, “Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials,” Lipids in Health and Disease, vol. 11, article 42, 2012. View at Publisher · View at Google Scholar
  18. M. P. Ponda, X. Huang, M. A. Odeh, J. L. Breslow, and H. W. Kaufman, “Vitamin D may not improve lipid levels: a serial clinical laboratory data study,” Circulation, vol. 126, no. 3, pp. 270–277, 2012. View at Publisher · View at Google Scholar
  19. R. Jorde and G. Grimnes, “Vitamin D and lipids: do we really need more studies?” Circulation, vol. 126, no. 3, pp. 252–254, 2012. View at Publisher · View at Google Scholar
  20. P. R. Von Hurst, W. Stonehouse, and J. Coad, “Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a randomised, placebo-controlled trial,” British Journal of Nutrition, vol. 103, no. 4, pp. 549–555, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. P. S. George, E. R. Pearson, and M. D. Witham, “Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis,” Diabetic Medicine, vol. 29, no. 8, pp. e142–e150, 2012. View at Publisher · View at Google Scholar
  22. A. D. Wood, K. R. Secombes, F. Thies et al., “Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT,” Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 10, pp. 3557–3567, 2012. View at Publisher · View at Google Scholar
  23. A. D. Gepner, R. Ramamurthy, D. C. Krueger, and C. E. Korcarz, “A prospective randomized controlled trial of the effects of Vitamin D supplementation on cardiovascular disease risk,” PLoS ONE, vol. 7, no. 5, Article ID e36617, 2012. View at Publisher · View at Google Scholar
  24. R. Jorde, M. Sneve, P. A. Torjesen, Y. Figenschau, L. G. Goslash;ransson, and R. Omdal, “No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects,” Cytokine, vol. 50, no. 2, pp. 175–180, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Rejnmark, A. Avenell, T. Masud et al., “Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials,” Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 8, pp. 2670–2681, 2012. View at Publisher · View at Google Scholar
  26. S. Pilz, K. Kienreich, A. Tomaschitz et al., “Vitamin D and cardiovascular disease: update and outlook,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 243, pp. 83–91, 2012. View at Google Scholar
  27. K. Kupferschmidt, “Uncertain verdict as vitamin D goes on trial,” Science, vol. 337, no. 6101, pp. 1476–1478, 2012. View at Publisher · View at Google Scholar
  28. N. M. Van Schoor and P. Lips, “Worldwide vitamin D status,” Best Practice and Research, vol. 25, no. 4, pp. 671–680, 2011. View at Publisher · View at Google Scholar
  29. S. Pilz, F. Rutters, and J. M. Dekker, “Disease prevention: vitamin D trials,” Science, vol. 338, no. 6109, p. 883, 883. View at Publisher · View at Google Scholar