International Scholarly Research Notices / 2013 / Article / Tab 1

Clinical Study

Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø

Table 1

Baseline characteristics in all subjects, the four separate studies, and according to intervention.

All subjectsObesity studyInsulin sensitivity studyBone density studyDepression studyIntervention, pooled data
Vitamin DPlacebo

92833394273228523405
Men (%)29.938.452.1043.932.127.2
Age (years)54.2 (11.3)49.2 (11.2)52.1 (9.2)63.1 (7.2)51.8 (10.2)53.1 (11.6)*55.7 (10.8)
Using lipid medication (%)7.33.95.311.48.85.99.4
BMI (kg/m2)29.2 (5.6)34.6 (3.9)26.8 (3.0)24.7 (3.3)27.7 (4.1)29.7 (5.5)*28.6 (5.6)
Serum 25(OH)D (nmol/L)55.9 (20.9)54.1 (16.8)40.8 (13.1)71.0 (22.6)47.5 (15.6)55.9 (20.6)56.4 (21.3)
Serum calcium (mmol/L)2.32 (0.09)2.31 (0.10)2.31 (0.09)2.36 (0.08)2.28 (0.08)2.32 (0.10)2.32 (0.09)
Serum PTH (pmol/L)5.17 (1.72)5.41 (1.71)5.20 (1.52)5.05 (1.65)4.98 (1.87)5.16 (1.65)5.20 (1.82)
Serum TC (mmol/L)5.56 (1.00)5.41 (1.00)5.57 (1.07)5.65 (0.92)5.64 (1.05)5.56 (1.01)5.55 (0.99)
Serum TG (mmol/L)1.40 (0.84)1.57 (0.93)1.25 (0.85)1.11 (0.51)1.59 (0.91)1.43 (0.89)1.37 (0.79)
Serum HDL-C (mmol/L)1.57 (0.48)1.40 (0.37)1.50 (0.40)1.88 (0.48)1.47 (0.46)1.55 (0.46)1.59 (0.50)
Serum LDL-C (mmol/L)3.66 (0.94)3.86 (0.95)3.51 (0.99)3.53 (0.85)3.57 (0.95)3.69 (0.94)3.61 (0.94)
Serum Apo A1 (g/L)1.56 (0.29)1.43 (0.25)1.52 (0.28)1.75 (0.26)1.55 (0.29)1.55 (0.29)1.57 (0.29)
Serum Apo B (g/L)0.98 (0.24)1.03 (0.23)0.95 (0.26)0.96 (0.22)0.97 (0.25)0.99 (0.24)0.98 (0.24)
HbA1c (%)5.65 (0.35)5.65 (0.36)5.56 (0.36)5.71 (0.34)5.64 (0.36)5.65 (0.36)5.67 (0.35)
Serum HS-CRP (mg/L)1.45 (0.77, 3.22)2.47 (1.34, 4.51)1.10 (0.59, 2.55)1.02 (0.50, 2.01)1.28 (0.77, 2.96)1.51 (0.77, 3.35)1.42 (0.78, 3.16)

Data are shown as mean (SD) or median (25, 75 percentile). BMI: body mass index; 25(OH)D: 25-hydroxyvitamin D; PTH: parathyroid hormone; TC: total cholesterol; TG: triglycerides; HDL-C: HDL cholesterol; LDL-C: LDL cholesterol; Apo A1: apolipoprotein A1; Apo B: apolipoprotein B; HbA1c: glycated hemoglobin; HS-CRP: high sensitivity C-reactive protein.
versus placebo group; Student’s t-test.