Oxaliplatin and Bolus-Modulated 5-Fluorouracil as a Second-Line Treatment for Advanced Pancreatic Cancer: Can Bolus Regimens Replace FOLFOX When Considered for Second Line?

Table 2

Patients with grade 3 or 4 toxicity by the NCI Common Toxicity Criteria version 3.0.

Characteristics	FLOX arm		3-week arm		𝑃 value
	Grade III	Grade IV	Grade III	Grade IV
Diarrhea	4 (16%)	1 (4%)	4 (16%)	1 (4%)	.11
Dehydration	2 (8%)	—	1 (4%)	—	.09
Nausea	1 (4%)	—	2 (8%)	—	.101
Vomiting	3 (12%)	—	1 (4%)	—	.07
Stomatitis	1 (4%)	—	1 (4%)	—	—
Hematological
Neutropenia	1 (4%)		1 (4%)	—	—
Anaemia	2 (8%)		1 (4%)	—	.089
Thrombocytopenia	—	—	—
Neurosensory	1 (4%)	—	1 (4%)	—	—
Thrombosis and embolism	1 (4%)	—	1 (4%)	—	—
Liver
Elevated transaminases	2 (8%)	—	3 (4%)	—	.21