Table of Contents
ISRN Neurology
Volume 2013 (2013), Article ID 371034, 6 pages
http://dx.doi.org/10.1155/2013/371034
Research Article

Organochlorine Pesticide Levels and Risk of Parkinson’s Disease in North Indian Population

1Department of Neurochemistry, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi 110095, India
2Environmental Biochemistry Laboratory, Department of Biochemistry, UCMS & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110095, India
3Department of Neurology, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi 110095, India
4Health Centre, Institute of Nuclear Medicine and Allied Sciences, DRDO, Timarpur, Delhi 110054, India

Received 21 May 2013; Accepted 18 June 2013

Academic Editors: C.-M. Chen, A. Conti, T. den Heijer, C.-Y. Hsu, and D. Mathieu

Copyright © 2013 Neelam Chhillar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The cause of Parkinson’s disease (PD) remains elusive, but environmental chemical exposures have been postulated to be involved in the etiology of PD. We examined the association between the persistent organochlorine pesticides (OCPs) and PD in the North Indian population. This case control study included 70 PD and 75 control subjects in the age group of 50 to 85 years. Blood samples were collected and high-purity grade hexane and acetone (2 : 1 ratio) were used for extraction of organochlorine residues. OCPs (hexachlorocyclohexane (HCH), aldrin, dieldrin, endosulfan, pp′-Dichlorodiphenyldichloroethylene (pp′-DDE), op′-DDE, pp′- Dichlorodiphenyltrichloroethane (pp′-DDT), op′-DDT, pp′-dichlorodiphenyldichloroethane (pp′-DDD) and op′-DDD) were quantitatively estimated by using gas chromatography. The most frequently detected OCP was dieldrin, which was present in 9.3% of control and 61.4% of PD. The strongest predictor was -hexachlorocyclohexane ( -HCH), which reported an odds ratio of 2.566, indicating that for every additional one unit of -HCH, patients had 2.566 times more chances of presence of PD. This study indicates that increased level of -HCH and dieldrin may be associated with the risk of PD.