Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling

Figure 4

Effect of GT3-PTX combination on peripheral blood cells. Mice (𝑛=8) treated with various treatment groups (vehicle, 100 mg/kg PTX, 200 mg/kg GT3, 200 mg/kg GT3 plus 100 mg/kg PTX) were exposed to 8 Gy TBI. Corresponding unirradiated controls were also included in the experiment. (a) and (b) show WBC and ANC over a period of 30 days. GT3-PTX combination shows accelerated recovery in WBC (^∗𝑃=0.03) and ANC (^∗𝑃=0.04) at day 7. At day 30, all irradiated groups reached the normal levels.

(a)

(b)