Table of Contents
ISRN Toxicology
Volume 2013 (2013), Article ID 397524, 6 pages
http://dx.doi.org/10.1155/2013/397524
Research Article

Cytotoxic Effects of Benzene Metabolites on Human Sperm Function: An In Vitro Study

Department of Human Genetics, Biomedical Technology and Zoology, Gujarat University, Ahmedabad, Gujarat 380009, India

Received 19 September 2013; Accepted 23 October 2013

Academic Editors: A. Cruz, A. I. Haza, M. G. Robson, and M. P. Singh

Copyright © 2013 Priyanka Mandani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Wallace, “Environmental exposure to benzene: an update,” Environmental Health Perspectives, vol. 104, supplement 6, pp. 1129–1136, 1996. View at Google Scholar · View at Scopus
  2. A. T. S. D. R. Agency for Toxic Substances and Disease Registry, “Toxicological profile for benzene,” US DHHS PB/98/101157/AS, Agency for Toxic Substances and Disease Registry, 1997. View at Google Scholar
  3. C. P. Weisel, “Benzene exposure: an overview of monitoring methods and their findings,” Chemico-Biological Interactions, vol. 184, no. 1-2, pp. 58–66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. P. J. Sabourin, B. T. Chen, and G. Lucier, “Effect of dose on the absorption and excretion of [14C] benzene administered orally or by inhalation in rats and mice,” Toxicology and Applied Pharmacology, vol. 87, no. 2, pp. 325–336, 1987. View at Google Scholar · View at Scopus
  5. T. A. McDonald, N. T. Holland, C. Skibola, P. Duramad, and M. T. Smith, “Hypothesis: phenol and hydroquinone derived mainly from diet and gastrointestinal flora activity are causal factors in leukemia,” Leukemia, vol. 15, no. 1, pp. 10–20, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. M. D. Shelby and K. L. Witt, “Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests,” Environmental and Molecular Mutagenesis, vol. 25, no. 4, pp. 302–313, 1995. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Bulsiewicz, “The influence of phenol on chromosomes of mice (Musimusculus) in the process of spermatogenesis,” Folia Morphologica, vol. 36, no. 1, pp. 3–22, 1977. View at Google Scholar · View at Scopus
  8. O. J. D'Cruz, A. Vassilev, and F. M. Uckun, “Studies in humans on the mechanism of potent spermicidal and apoptosis- inducing activities of vanadocene complexes,” Biology of Reproduction, vol. 62, no. 4, pp. 939–949, 2000. View at Google Scholar · View at Scopus
  9. R. J. Aitken and G. N. De Luliis, “On the possible origins of DNA damage in human spermatozoa,” Molecular Human Reproduction, vol. 16, no. 1, pp. 3–13, 2010. View at Publisher · View at Google Scholar
  10. D. Sakkas and J. G. Alvarez, “Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis,” Fertility and Sterility, vol. 93, no. 4, pp. 1027–1036, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. D. P. Evenson, K. L. Larson, and L. K. Jost, “Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques,” Journal of Andrology, vol. 23, no. 1, pp. 25–43, 2002. View at Google Scholar · View at Scopus
  12. WHO, Laboratory Manual for the Examination and Processing of Human Semen, Cambridge University Press, Cambridge, UK, 5th edition, 2010.
  13. P. Talbot and R. S. Chacon, “A triple-stain technique for evaluating normal acrosome reactions of human sperm,” Journal of Experimental Zoology, vol. 215, no. 2, pp. 201–208, 1981. View at Google Scholar · View at Scopus
  14. R. I. Tejada, J. C. Mitchell, and A. Norman, “A test for the practical evaluation of male fertility by acridine orange (AO) fluorescence,” Fertility and Sterility, vol. 42, no. 1, pp. 87–91, 1984. View at Google Scholar · View at Scopus
  15. D. Sammett, E. W. Lee, J. J. Kocsis, and R. Snyder, “Partial hepatectomy reduces both metabolism and toxicity of benzene: chapter 1,” Journal of Toxicology and Environmental Health, vol. 5, no. 5, pp. 785–792, 1979. View at Google Scholar · View at Scopus
  16. R. K. Singh and F. W. Bansode, “Benzene-induced histopathological changes and germ cell population dynamics in testes of Sprague Dawley rats,” Journal of Environmental Biology, vol. 32, no. 6, pp. 687–694, 2011. View at Google Scholar · View at Scopus
  17. H. J. Badham and L. M. Winn, “In utero exposure to benzene disrupts fetal hematopoietic progenitor cell growth via reactive oxygen species,” Toxicological Sciences, vol. 113, no. 1, pp. 207–215, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Turhan and E. Dere, “The effect of benzene on the activity of adenosine deaminase in tissues of rats,” Journal of Biochemistry and Molecular Biology, vol. 40, no. 3, pp. 295–301, 2007. View at Google Scholar · View at Scopus
  19. S. Aiso, H. Arito, T. Nishizawa, K. Nagano, S. Yamamoto, and T. Matsushima, “Thirteen-week inhalation toxicity of p-dichlorobenzene in mice and rats,” Journal of Occupational Health, vol. 47, no. 3, pp. 249–260, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Steiber, J. Kerner, and C. L. Hoppel, “Carnitine: a nutritional, biosynthetic, and functional perspective,” Molecular Aspects of Medicine, vol. 25, no. 5-6, pp. 455–473, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Inaba, “Molecular architecture of the sperm flagella: molecules for motility and signaling,” Zoological Science, vol. 20, no. 9, pp. 1043–1056, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. C. B. Lindemann, “Structural-functional relationships of the dynein, spokes, and central-pair projections predicted from an analysis of the forces acting within a flagellum,” Biophysical Journal, vol. 84, no. 6, pp. 4115–4126, 2003. View at Google Scholar · View at Scopus
  23. C. Eberhard, M. B. Hermann, and N. M. A. Susan, Andrology: Male Reproductive Health and Dysfunction, completely revised and updated edition, Springer, New York, NY, USA, 3rd edition, 2010.
  24. D. E. Chapman, M. J. Namkung, and M. R. Juchau, “Benzene and benzene metabolites as embryotoxic agents: effects on cultured rat embryos,” Toxicology and Applied Pharmacology, vol. 128, no. 1, pp. 129–137, 1994. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Chen and D. A. Eastmond, “Synergistic increase in chromosomal breakage within the euchromatin induced by an interaction of the benzene metabolites phenol and hydroquinone in mice,” Carcinogenesis, vol. 16, no. 8, pp. 1963–1969, 1995. View at Google Scholar · View at Scopus
  26. T. J. Atkinson, “A review of the role of benzene metabolites and mechanisms in malignant transformation: summative evidence for a lack of research in nonmyelogenous cancer types,” International Journal of Hygiene and Environmental Health, vol. 212, no. 1, pp. 1–10, 2009. View at Publisher · View at Google Scholar · View at Scopus