Table of Contents
ISRN Gastroenterology
Volume 2013 (2013), Article ID 415417, 7 pages
http://dx.doi.org/10.1155/2013/415417
Research Article

Enhanced Blood Lymphocytes Apoptosis in Children with Inflammatory Bowel Disease

1Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
2Department of Clinical Pathology/Hematology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
3Ministry of Health, Cairo 11566, Egypt

Received 28 May 2013; Accepted 24 July 2013

Academic Editors: A. Amedei and L. J. Hofseth

Copyright © 2013 M. A. El-Hodhod et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this work was to measure peripheral lymphocyte apoptosis during IBD flare and remission. Subjects and Methods. Flow-cytometric assessment of apoptosis of peripheral blood lymphocytes (PBL) was assessed in 30 children with IBD (16 with ulcerative colitis and 14 with Crohn’s disease) compared to 22, age and sex matched, healthy children. This was carried out during a flare, whether in newly diagnosed or relapsing patients, and after achievement of remission. Clinical findings, complete blood count, liver transaminases, and kidney functions were assessed. Results. Early apoptotic and late apoptotic/necrotic lymphocytes were significantly higher during IBD flare compared to controls ( and <0.01, resp., in ulcerative colitis and and <0.01, resp., in Crohn’s disease patients). Remission values were significantly decreased but did not come back to the control levels. Early apoptotic values were significantly related to joint involvement in IBD patients ( ). Conclusions. We can speculate a systemic nature of IBD as evident by enhanced peripheral lymphocyte apoptosis. This is related, to a great extent, to the disease process as it is more deranged in flare than in remission. Relation of this derangement to extraintestinal manifestations needs a special attention.