Table of Contents
ISRN Gastroenterology
Volume 2013 (2013), Article ID 415417, 7 pages
http://dx.doi.org/10.1155/2013/415417
Research Article

Enhanced Blood Lymphocytes Apoptosis in Children with Inflammatory Bowel Disease

1Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
2Department of Clinical Pathology/Hematology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
3Ministry of Health, Cairo 11566, Egypt

Received 28 May 2013; Accepted 24 July 2013

Academic Editors: A. Amedei and L. J. Hofseth

Copyright © 2013 M. A. El-Hodhod et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Scaldaferri and C. Fiocchi, “Inflammatory bowel disease: progress and current concepts of etiopathogenesis,” Journal of Digestive Diseases, vol. 8, no. 4, pp. 171–178, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. E. V. Tsianos and K. Katsanos, “Do we really understand what the immunological disturbances in inflammatory bowel disease mean?” World Journal of Gastroenterology, vol. 15, no. 5, pp. 521–525, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Khor, A. Gardet, and R. J. Xavier, “Genetics and pathogenesis of inflammatory bowel disease,” Nature, vol. 474, no. 7351, pp. 307–317, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Williams, D. Walker, and T. R. Orchard, “Extraintestinal manifestations of inflammatory bowel disease,” Current Gastroenterology Reports, vol. 10, no. 6, pp. 597–605, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. F. A. Jose, E. A. Garnett, E. Vittinghoff et al., “Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 15, no. 1, pp. 63–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. R. Vavricka, L. Brun, P. Ballabeni et al., “Frequency and risk factors for extraintestinal manifestations in the swiss inflammatory bowel disease cohort,” American Journal of Gastroenterology, vol. 106, no. 1, pp. 110–119, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Ortiz, L. Cortés, H. González-Márquez, J. L. Gómez, C. González, and E. Cortés, “Flow cytometric analysis of spontaneous and dexamethasone-induced apoptosis in thymocytes from severely malnourished rats,” British Journal of Nutrition, vol. 86, no. 5, pp. 545–548, 2001. View at Google Scholar · View at Scopus
  8. G. Koopman, C. P. M. Reutelingsperger, G. A. M. Kuijten, R. M. J. Keehnen, S. T. Pals, and M. H. J. van Oers, “Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis,” Blood, vol. 84, no. 5, pp. 1415–1420, 1994. View at Google Scholar · View at Scopus
  9. T. T. MacDonald and G. Monteleone, “Immunity, inflammation, and allergy in the gut,” Science, vol. 307, no. 5717, pp. 1920–1925, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. L. E. Smythies, M. Sellers, R. H. Clements et al., “Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity,” Journal of Clinical Investigation, vol. 115, no. 1, pp. 66–75, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Sturm, “What is the role of apoptosis in the normal and inflamed intestine?” Inflammatory Bowel Diseases, vol. 14, supplement 2, pp. S113–S114, 2008. View at Google Scholar · View at Scopus
  12. A. Di Sabatino, R. Ciccocioppo, O. Luinetti et al., “Increased enterocyte apoptosis in inflamed areas of Crohn's disease,” Diseases of the Colon and Rectum, vol. 46, no. 11, pp. 1498–1507, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. M. F. Neurath, S. Finotto, I. Fuss, M. Boirivant, P. R. Galle, and W. Strober, “Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question,” Trends in Immunology, vol. 22, no. 1, pp. 21–26, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. J. C. Escher, “Inflammatory bowel disease in children and adolescents: recommendations for diagnosis—the Porto criteria,” Journal of Pediatric Gastroenterology and Nutrition, vol. 41, no. 1, pp. 1–7, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Turner, A. R. Otley, D. Mack et al., “Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study,” Gastroenterology, vol. 133, no. 2, pp. 423–432, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. M. A. Shepanski, J. E. Markowitz, P. Mamula, L. B. Hurd, and R. N. Baldassano, “Is an abbreviated pediatric Crohn's disease activity index better than the original?” Journal of Pediatric Gastroenterology and Nutrition, vol. 39, no. 1, pp. 68–72, 2004. View at Google Scholar · View at Scopus
  17. C. W. Lees, J. C. Barrett, M. Parkes, and J. Satsangi, “New IBD genetics: common pathways with other diseases,” Gut, vol. 60, no. 12, pp. 1739–1753, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. P. T. Sattianayagam, P. N. Hawkins, and J. D. Gillmore, “Systemic amyloidosis and the gastrointestinal tract,” Nature Reviews Gastroenterology and Hepatology, vol. 6, no. 10, pp. 608–617, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Danese, S. Semeraro, A. Papa et al., “Extraintestinal manifestation in inflammatory bowel disease,” World Journal of Gastroenterology, vol. 11, no. 46, pp. 7227–7236, 2005. View at Google Scholar · View at Scopus
  20. F. Fava and S. Danese, “Intestinal microbiota in inflammatory bowel disease: friend of foe?” World Journal of Gastroenterology, vol. 17, no. 5, pp. 557–566, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. R. W. Chapman, M. Cottone, and W. S. Selby, “Serum autoantibodies, ulcerative colitis and primary sclerosing cholangitis,” Gut, vol. 27, no. 1, pp. 86–91, 1986. View at Google Scholar · View at Scopus
  22. X. Geng, L. Biancone, H. H. D. Hui Hui Dai et al., “Tropomyosin isoforms in intestinal mucosa: production of autoantibodies to tropomyosin isoforms in ulcerative colitis,” Gastroenterology, vol. 114, no. 5, pp. 912–922, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Hildeman, T. Jorgensen, J. Kappler, and P. Marrack, “Apoptosis and the homeostatic control of immune responses,” Current Opinion in Immunology, vol. 19, no. 5, pp. 516–521, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. J. C. Rathmell and C. B. Thompson, “Pathways of apoptosis in lymphocyte development, homeostasis, and disease,” Cell, vol. 109, no. 2, pp. S97–S107, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. E. J. Bodar, J. C. H. van der Hilst, W. van Heerde, J. W. M. van der Meer, J. P. H. Drenth, and A. Simon, “Defective apoptosis of peripheral-blood lymphocytes in hyper-IgD and periodic fever syndrome,” Blood, vol. 109, no. 6, pp. 2416–2418, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Delogu, G. Famularo, S. Moretti et al., “Interleukin-10 and apoptotic death of circulating lymphocytes in surgical/anesthesia trauma,” Journal of Trauma, vol. 51, no. 1, pp. 92–97, 2001. View at Google Scholar · View at Scopus
  27. M. G. Neuman, “Immune dysfunction in inflammatory bowel disease,” Translational Research, vol. 149, no. 4, pp. 173–186, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. J. J. O'Shea, A. Ma, and P. Lipsky, “Cytokines and autoimmunity,” Nature Reviews Immunology, vol. 2, no. 1, pp. 37–45, 2002. View at Google Scholar · View at Scopus
  29. V. A. Fadok, D. L. Bratton, L. Guthrie, and P. M. Henson, “Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases,” Journal of Immunology, vol. 166, no. 11, pp. 6847–6854, 2001. View at Google Scholar · View at Scopus
  30. R. E. Voll, M. Herrmann, E. A. Roth, C. Stach, J. R. Kalden, and I. Girkontaite, “Immunosuppressive effects of apoptotic cells,” Nature, vol. 390, no. 6658, pp. 350–351, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Nakajima, H. Iijima, S. Egawa et al., “Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease,” Nutrition, vol. 27, no. 10, pp. 1023–1028, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. T. O'malley and R. Heuberger, “Vitamin D status and supplementation in pediatric gastrointestinal disease,” Journal for Specialists in Pediatric Nursing, vol. 16, no. 2, pp. 140–150, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Ardizzone, A. Cassinotti, M. Bevilacqua, M. Clerici, and G. B. Porro, “Vitamin D and inflammatory bowel disease,” Vitamins and Hormones, vol. 86, pp. 367–377, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. A. D. Levin, V. Wadhera, S. T. Leach et al., “Vitamin D deficiency in children with inflammatory bowel disease,” Digestive Diseases and Sciences, vol. 56, no. 3, pp. 830–836, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Bager, R. Befrits, O. Wikman et al., “The prevalence of anemia and iron deficiency in IBD outpatients in Scandinavia,” Scandinavian Journal of Gastroenterology, vol. 46, no. 3, pp. 304–309, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Yakut, Y. Üstün, G. Kabaçam, and I. Soykan, “Serum vitamin B12 and folate status in patients with inflammatory bowel diseases,” European Journal of Internal Medicine, vol. 21, no. 4, pp. 320–323, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Nell, S. Suerbaum, and C. Josenhans, “The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models,” Nature Reviews Microbiology, vol. 8, no. 8, pp. 564–577, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Lerner, T. M. Rossi, B. Park, B. Albini, and E. Lebenthal, “Serum antibodies to cow's milk proteins in pediatric inflammatory bowel disease. Crohn's disease versus ulcerative colitis,” Acta Paediatrica Scandinavica, vol. 78, no. 3, pp. 384–389, 1989. View at Google Scholar · View at Scopus
  39. C. Abraham and R. Medzhitov, “Interactions between the host innate immune system and microbes in inflammatory bowel disease,” Gastroenterology, vol. 140, no. 6, pp. 1729–1737, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. E. M. Gravallese and F. G. Kantrowitz, “Arthritic manifestations of inflammatory bowel disease,” American Journal of Gastroenterology, vol. 83, no. 7, pp. 703–709, 1988. View at Google Scholar · View at Scopus
  41. T. R. Orchard, B. P. Wordsworth, and D. P. Jewell, “Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history,” Gut, vol. 42, no. 3, pp. 387–391, 1998. View at Google Scholar · View at Scopus
  42. K. de Vlam, H. Mielants, C. Cuvelier, F. De Keyser, E. M. Veys, and M. De Vos, “Spondyloarthropathy is underestimated in inflammatory bowel disease: prevalence and HLA association,” Journal of Rheumatology, vol. 27, no. 12, pp. 2860–2865, 2000. View at Google Scholar · View at Scopus
  43. C. Veltkamp, M. Anstaett, K. Wahl et al., “Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment,” Gut, vol. 60, no. 10, pp. 1345–1353, 2011. View at Publisher · View at Google Scholar · View at Scopus