Table of Contents
ISRN Neuroscience
Volume 2013 (2013), Article ID 423931, 10 pages
http://dx.doi.org/10.1155/2013/423931
Research Article

Myosins Are Differentially Expressed under Oxidative Stress in Chronic Streptozotocin-Induced Diabetic Rat Brains

1Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, MG, Brazil
2Federal University of Juiz de Fora, Governador Valadares, MG, Brazil
3Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil
4Department of Chemistry, Physic, and Mathematic, University of Ribeirão Preto, Ribeirão Preto, SP, Brazil

Received 5 June 2013; Accepted 17 August 2013

Academic Editors: H. Ochi, A. Unal, and A. Witting

Copyright © 2013 Luciana Karen Calábria et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. E. Lamb and B. J. Goldstein, “Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function,” International Journal of Clinical Practice, vol. 62, no. 7, pp. 1087–1095, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Nishikawa, D. Edelstein, X. L. Du et al., “Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage,” Nature, vol. 404, no. 6779, pp. 787–790, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. A. M. A. Brands, R. P. C. Kessels, E. H. F. de Haan, L. J. Kappelle, and G. J. Biessels, “Cerebral dysfunction in type 1 diabetes: effects of insulin, vascular risk factors and blood-glucose levels,” European Journal of Pharmacology, vol. 490, no. 1–3, pp. 159–168, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. J. W. Russell, D. Golovoy, A. M. Vincent et al., “High glucose-induced oxidative stress and mitochondrial dysfunction in nuerons,” The FASEB Journal, vol. 16, no. 13, pp. 1738–1748, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Tayarani, J. Chaudiere, J.-M. Lefauconnier, and J.-M. Bourre, “Enzymatic protection against peroxidative damage in isolated brain capillaries,” Journal of Neurochemistry, vol. 48, no. 5, pp. 1399–1402, 1987. View at Google Scholar · View at Scopus
  6. B. Hammond, H. A. Kontos, and M. L. Hess, “Oxygen radicals in the adult respiratory distress syndrome, in myocardial ischemia and reperfusion injury, and in cerebral vascular damage,” Canadian Journal of Physiology and Pharmacology, vol. 63, no. 3, pp. 173–187, 1985. View at Google Scholar · View at Scopus
  7. G. del Boccio, D. Lapenna, E. Porreca et al., “Aortic antioxidant defence mechanisms: time-related changes in cholesterol-fed rabbits,” Atherosclerosis, vol. 81, no. 2, pp. 127–135, 1990. View at Google Scholar · View at Scopus
  8. D. Bonnefont-Rousselot, “Glucose and reactive oxygen species,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 5, no. 5, pp. 561–568, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Bonnefont-Rousselot, J. P. Bastard, M. C. Jaudon, and J. Delattre, “Consequences of the diabetic status on the oxidant/antioxidant balance,” Diabetes and Metabolism, vol. 26, no. 3, pp. 163–176, 2000. View at Google Scholar · View at Scopus
  10. R. Rahimi, S. Nikfar, B. Larijani, and M. Abdollahi, “A review on the role of antioxidants in the management of diabetes and its complications,” Biomedicine and Pharmacotherapy, vol. 59, no. 7, pp. 365–373, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Baydas, H. Canatan, and A. Turkoglu, “Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus,” Journal of Pineal Research, vol. 32, no. 4, pp. 225–230, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. C. L. Hawkins and M. J. Davies, “Generation and propagation of radical reactions on proteins,” Biochimica et Biophysica Acta, vol. 1504, no. 2-3, pp. 196–219, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Artola, “Diabetes-, stress- and ageing-related changes in synaptic plasticity in hippocampus and neocortex—the same metaplastic process?” European Journal of Pharmacology, vol. 585, no. 1, pp. 153–162, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. W. H. Gispen and G.-J. Biessels, “Cognition and synaptic plasticity in diabetes mellitus,” Trends in Neurosciences, vol. 23, no. 11, pp. 542–549, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Aragno, R. Mastrocola, M. G. Catalano, E. Brignardello, O. Danni, and G. Boccuzzi, “Oxidative stress impairs skeletal muscle repair in diabetic rats,” Diabetes, vol. 53, no. 4, pp. 1082–1088, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Coirault, A. Guellich, T. Barbry, J. L. Samuel, B. Riou, and Y. Lecarpentier, “Oxidative stress of myosin contributes to skeletal muscle dysfunction in rats with chronic heart failure,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 292, no. 2, pp. H1009–H1017, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. B. J. Foth, M. C. Goedecke, and D. Soldati, “New insights into myosin evolution and classification,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 10, pp. 3681–3686, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. J. R. Sellers, “Myosins: a diverse superfamily,” Biochimica et Biophysica Acta, vol. 1496, no. 1, pp. 3–22, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Bose, A. Guilherme, S. I. Robida et al., “Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c,” Nature, vol. 420, no. 6917, pp. 821–824, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. M. E. Brown and P. C. Bridgman, “Myosin Function in Nervous and Sensory Systems,” Journal of Neurobiology, vol. 58, no. 1, pp. 118–130, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. L. K. Calábria, G. C. N. da Cruz, R. Nascimento et al., “Overexpression of myosin-IIB in the brain of a rat model of streptozotocin-induced diabetes,” Journal of the Neurological Sciences, vol. 303, no. 1-2, pp. 43–49, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. L. T. K. Chung, T. Hosaka, N. Harada et al., “Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes,” Biochemical and Biophysical Research Communications, vol. 391, no. 1, pp. 995–999, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. A. V. da Costa, L. K. Calábria, R. Nascimento, W. J. Carvalho, L. R. Goulart, and F. S. Espindola, “The streptozotocin-induced rat model of diabetes mellitus evidences significant reduction of myosin-Va expression in the brain,” Metabolic Brain Disease, vol. 26, no. 4, pp. 247–251, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Yoshizaki, T. Imamura, J. L. Babendure, J.-C. Lu, N. Sonoda, and J. M. Olefsky, “Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bβ) substrate modulating GLUT4 vesicle translocation,” Molecular and Cellular Biology, vol. 27, no. 14, pp. 5172–5183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. A. V. da Costa, L. K. Calabria, F. B. Furtado et al., “Neuroprotective effects of Pouteria ramiflora (Mart.) Radlk (Sapotaceae) extract on the brains of rats with streptozotocin-induced diabetes,” Metabolic Brain Disease, vol. 28, no. 3, pp. 411–419, 2013. View at Google Scholar
  26. C. Beaulieu, R. Kestekian, J. Havrankova, and M. Gascon-Barre, “Calcium is essential in normalizing intolerance to glucose that accompanies vitamin D depletion in vivo,” Diabetes, vol. 42, no. 1, pp. 35–43, 1993. View at Google Scholar · View at Scopus
  27. L. A. Martini, A. S. Catania, and S. R. G. Ferreira, “Role of vitamins and minerals in prevention and management of type 2 diabetes mellitus,” Nutrition Reviews, vol. 68, no. 6, pp. 341–354, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. A. G. Pittas, J. Lau, F. B. Hu, and B. Dawson-Hughes, “Review: the role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 6, pp. 2017–2029, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. M. F. Essop, W. A. Chan, and S. Hattingh, “Proteomic analysis of mitochondrial proteins in a mouse model of type 2 diabetes,” Cardiovascular Journal of Africa, vol. 22, no. 4, pp. 175–178, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Persengiev, B. P. C. Koeleman, K. Downes et al., “Association analysis of myosin IXB and type 1 diabetes,” Human Immunology, vol. 71, no. 6, pp. 598–601, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. P. G. Reeves, F. H. Nielsen, and G. C. Fahey Jr., “AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet,” Journal of Nutrition, vol. 123, no. 11, pp. 1939–1951, 1993. View at Google Scholar · View at Scopus
  32. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976. View at Google Scholar · View at Scopus
  33. H. Aebi, H. Suter, and R. N. Feinstein, “Activity and stability of catalase in blood and tissues of normal and acatalasemic mice,” Biochemical Genetics, vol. 2, no. 3, pp. 245–251, 1968. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Towbin, T. Staehelin, and J. Gordon, “Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications,” Proceedings of the National Academy of Sciences of the United States of America, vol. 76, no. 9, pp. 4350–4354, 1979. View at Google Scholar · View at Scopus
  35. R. E. Larson, J. A. Ferro, and E. A. Queiroz, “Isolation and purification of actomyosin ATPase from mammalian brain,” Journal of Neuroscience Methods, vol. 16, no. 1, pp. 47–58, 1986. View at Google Scholar · View at Scopus
  36. D. M. Suter, F. S. Espindola, C. H. Lin, P. Forscher, and M. S. Mooseker, “Localization of unconventional myosins V and VI in neuronal growth cones,” Journal of Neurobiology, vol. 42, pp. 370–382, 2000. View at Google Scholar
  37. E. M. Espreafico, R. E. Cheney, M. Matteoli et al., “Primary structure and cellular localization of chicken brain myosin-V (p190), an unconventional myosin with calmodulin light chains,” Journal of Cell Biology, vol. 119, no. 6, pp. 1541–1557, 1992. View at Publisher · View at Google Scholar · View at Scopus
  38. J. L. Yin, N. A. Shackel, A. Zekry et al., “Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I,” Immunology and Cell Biology, vol. 79, no. 3, pp. 213–221, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. P. A. Low, K. K. Nickander, and H. J. Tritschler, “The roles of oxidative stress and antioxidant. Treatment in experimental diabetic neuropathy,” Diabetes, vol. 46, supplement 2, pp. S38–S42, 1997. View at Google Scholar · View at Scopus
  40. F. Gardoni, A. Kamal, C. Bellone et al., “Effects of streptozotocin-diabetes on the hippocampal NMDA receptor complex in rats,” Journal of Neurochemistry, vol. 80, no. 3, pp. 438–447, 2002. View at Publisher · View at Google Scholar · View at Scopus
  41. E. Coleman, R. Judd, L. Hoe, J. Dennis, and P. Posner, “Effects of diabetes mellitus on astrocyte GFAP and glutamate transporters in the CNS,” Glia, vol. 48, no. 2, pp. 166–178, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. S. S. Kamboj, K. Chopra, and R. Sandhir, “Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes,” Metabolic Brain Disease, vol. 23, no. 4, pp. 427–443, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. J. P. Hernández-Fonseca, J. Rincón, A. Pedreañez et al., “Structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats,” Experimental Diabetes Research, vol. 2009, Article ID 329632, 12 pages, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. R. J. Gomes, C. A. M. de Oliveira, C. Ribeiro et al., “Effects of exercise training on hippocampus concentrations of insulin and IGF-1 in diabetic rats,” Hippocampus, vol. 19, no. 10, pp. 981–987, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. K. Asplund, K. Grankvist, S. Marklund, and I. B. Taljedal, “Partial protection against streptozotocin-induced hyperglycaemia by superoxide dismutase linked to polyethylene glycol,” Acta Endocrinologica, vol. 107, no. 3, pp. 390–394, 1984. View at Google Scholar · View at Scopus
  46. R. Kakkar, J. Kalra, S. V. Mantha, and K. Prasad, “Lipid peroxidation and activity of antioxidant enzymes in diabetic rats,” Molecular and Cellular Biochemistry, vol. 151, no. 2, pp. 113–119, 1995. View at Publisher · View at Google Scholar · View at Scopus
  47. R. Kakkar, S. V. Mantha, J. Radhi, K. Prasad, and J. Kalra, “Antioxidant defense system in diabetic kidney: a time course study,” Life Sciences, vol. 60, no. 9, pp. 667–679, 1997. View at Publisher · View at Google Scholar · View at Scopus
  48. S. Genet, R. K. Kale, and N. Z. Baquer, “Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of vanadate and fenugreek (Trigonella foenum graecum),” Molecular and Cellular Biochemistry, vol. 236, no. 1-2, pp. 7–12, 2002. View at Publisher · View at Google Scholar · View at Scopus
  49. P. V. Limaye, N. Raghuram, and S. Sivakami, “Oxidative stress and gene expression of antioxidant enzymes in the renal cortex of streptozotocin-induced diabetic rats,” Molecular and Cellular Biochemistry, vol. 243, no. 1-2, pp. 147–152, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. S. R. Panneerselvam and S. Govindasamy, “Effect of sodium molybdate on the status of lipids, lipid peroxidation and antioxidant systems in alloxan-induced diabetic rats,” Clinica Chimica Acta, vol. 345, no. 1-2, pp. 93–98, 2004. View at Publisher · View at Google Scholar · View at Scopus
  51. B. Halliwell, “Reactive oxygen species and the central nervous system,” Journal of Neurochemistry, vol. 59, no. 5, pp. 1609–1623, 1992. View at Publisher · View at Google Scholar · View at Scopus
  52. N. N. Ulusu, M. Sahilli, A. Avci et al., “Pentose phosphate pathway, glutathione -dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E,” Neurochemical Research, vol. 28, no. 6, pp. 815–823, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. M. R. Siddiqui, A. Taha, K. Moorthy, M. E. Hussain, S. F. Basir, and N. Z. Baquer, “Amelioration of altered antioxidant status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains,” Journal of Biosciences, vol. 30, no. 4, pp. 483–490, 2005. View at Google Scholar · View at Scopus
  54. W.-C. Huang, S.-W. Juang, I.-M. Liu, T.-C. Chi, and J.-T. Cheng, “Changes of superoxide dismutase gene expression and activity in the brain of streptozotocin-induced diabetic rats,” Neuroscience Letters, vol. 275, no. 1, pp. 25–28, 1999. View at Publisher · View at Google Scholar · View at Scopus
  55. N. Sinha, N. Z. Baquer, and D. Sharma, “Anti-lipidperoxidative role of exogenous dehydroepiendrosterone (DHEA) administration in normal ageing rat brain,” Indian Journal of Experimental Biology, vol. 43, no. 5, pp. 420–424, 2005. View at Google Scholar · View at Scopus
  56. A. Kuhad and K. Chopra, “Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences,” European Journal of Pharmacology, vol. 576, no. 1–3, pp. 34–42, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. T. K. Makar, K. Rimpel-Lamhaouar, D. G. Abraham, V. S. Gokhale, and A. J. L. Cooper, “Antioxidant defense systems in the brains of type II diabetic mice,” Journal of Neurochemistry, vol. 65, no. 1, pp. 287–291, 1995. View at Google Scholar · View at Scopus
  58. O.-G. Kwag, S.-O. Kim, J.-H. Choi, I.-K. Rhee, M.-S. Choi, and S.-J. Rhee, “Vitamin E improves microsomal phospholipase A2 activity and the arachidonic acid cascade in kidney of diabetic rats,” Journal of Nutrition, vol. 131, no. 4, pp. 1297–1301, 2001. View at Google Scholar · View at Scopus
  59. J. S. Suresh Kumar and V. P. Menon, “Effect of diabetes on levels of lipid peroxides and glycolipids in rat brain,” Metabolism, vol. 42, no. 11, pp. 1435–1439, 1993. View at Publisher · View at Google Scholar · View at Scopus
  60. S. A. Wohaieb and D. V. Godin, “Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment,” Diabetes, vol. 36, no. 9, pp. 1014–1018, 1987. View at Google Scholar · View at Scopus
  61. Y. G. Özkaya, A. Agar, P. Yargiçoglu et al., “The effect of exercise on brain antioxidant status of diabetic rats,” Diabetes and Metabolism, vol. 28, no. 5, pp. 377–384, 2002. View at Google Scholar · View at Scopus
  62. V. M. Bhor, N. Raghuram, and S. Sivakami, “Oxidative damage and altered antioxidant enzyme activities in the small intestine of streptozotocin-induced diabetic rats,” International Journal of Biochemistry and Cell Biology, vol. 36, no. 1, pp. 89–97, 2004. View at Publisher · View at Google Scholar · View at Scopus
  63. M. B. Zemel, W. Thompson, A. Milstead, K. Morris, and P. Campbell, “Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults,” Obesity Research, vol. 12, no. 4, pp. 582–590, 2004. View at Google Scholar · View at Scopus
  64. I. H. de Boer, L. F. Tinker, S. Connelly et al., “Calcium plus vitamin D supplementation and the risk of incident diabetes in the women's health initiative,” Diabetes Care, vol. 31, no. 4, pp. 701–707, 2008. View at Publisher · View at Google Scholar · View at Scopus
  65. I. Fridovich, “Superoxide radical and superoxide dismutases,” Annual Review of Biochemistry, vol. 64, pp. 97–112, 1995. View at Google Scholar · View at Scopus
  66. M. Valko, H. Morris, and M. T. D. Cronin, “Metals, toxicity and oxidative stress,” Current Medicinal Chemistry, vol. 12, no. 10, pp. 1161–1208, 2005. View at Publisher · View at Google Scholar · View at Scopus
  67. C. G. Taylor, “Zinc, the pancreas, and diabetes: insights from rodent studies and future directions,” BioMetals, vol. 18, no. 4, pp. 305–312, 2005. View at Publisher · View at Google Scholar · View at Scopus
  68. C. Scheede-Bergdahl, M. Penkowa, J. Hidalgo et al., “Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes,” Diabetes, vol. 54, no. 11, pp. 3089–3094, 2005. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Beltramini, P. Zambenedetti, M. Raso, M. I. IbnlKayat, and P. Zatta, “The effect of Zn(II) and streptozotocin administration in the mouse brain,” Brain Research, vol. 1109, no. 1, pp. 207–218, 2006. View at Publisher · View at Google Scholar · View at Scopus
  70. C. G. Taylor, W. J. Bettger, and T. M. Bray, “Effect of dietary zinc or copper deficiency on the primary free radical defense system in rats,” Journal of Nutrition, vol. 118, no. 5, pp. 613–621, 1988. View at Google Scholar · View at Scopus
  71. H. Yoshida, K. Sasaki, Y. Hirowatari et al., “Increased serum iron may contribute to enhanced oxidation of low-density lipoprotein in smokers in part through changes in lipoxygenase and catalase,” Clinica Chimica Acta, vol. 345, no. 1-2, pp. 161–170, 2004. View at Publisher · View at Google Scholar · View at Scopus
  72. R. A. Kowluru, R. L. Engerman, and T. S. Kern, “Diabetes-induced metabolic abnormalities in myocardium: effect of antioxidant therapy,” Free Radical Research, vol. 32, no. 1, pp. 67–74, 2000. View at Google Scholar · View at Scopus
  73. M. Valko, D. Leibfritz, J. Moncol, M. T. D. Cronin, M. Mazur, and J. Telser, “Free radicals and antioxidants in normal physiological functions and human disease,” International Journal of Biochemistry and Cell Biology, vol. 39, no. 1, pp. 44–84, 2007. View at Publisher · View at Google Scholar · View at Scopus
  74. G. Paolisso, A. D'Amore, D. Giugliano, A. Ceriello, M. Varricchio, and F. D'Onofrio, “Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients,” American Journal of Clinical Nutrition, vol. 57, no. 5, pp. 650–656, 1993. View at Google Scholar · View at Scopus
  75. G. Paolisso, G. di Maro, D. Galzerano et al., “Pharmacological doses of vitamin E and insulin action in elderly subjects,” American Journal of Clinical Nutrition, vol. 59, no. 6, pp. 1291–1296, 1994. View at Google Scholar · View at Scopus
  76. N. C. Ward, J. H. Y. Wu, M. W. Clarke et al., “The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial,” Journal of Hypertension, vol. 25, no. 1, pp. 227–234, 2007. View at Publisher · View at Google Scholar · View at Scopus
  77. H. Yanagisawa, M. Sato, M. Nodera, and O. Wada, “Excessive zinc intake elevates systemic blood pressure levels in normotensive rats—potential role of superoxide-induced oxidative stress,” Journal of Hypertension, vol. 22, no. 3, pp. 543–550, 2004. View at Publisher · View at Google Scholar · View at Scopus
  78. K. Moorthy, D. Sharma, S. F. Basir, and N. Z. Baquer, “Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats,” Experimental Gerontology, vol. 40, no. 4, pp. 295–302, 2005. View at Publisher · View at Google Scholar · View at Scopus
  79. K. Moorthy, U. C. S. Yadav, M. R. Siddiqui et al., “Effect of hormone replacement therapy in normalizing age related neuronal markers in different age groups of naturally menopausal rats,” Biogerontology, vol. 6, no. 5, pp. 345–356, 2005. View at Publisher · View at Google Scholar · View at Scopus
  80. C. A. Grillo, G. G. Piroli, G. E. Wood, L. R. Reznikov, B. S. McEwen, and L. P. Reagan, “Immunocytochemical analysis of synaptic proteins provides new insights into diabetes-mediated plasticity in the rat hippocampus,” Neuroscience, vol. 136, no. 2, pp. 477–486, 2005. View at Publisher · View at Google Scholar · View at Scopus
  81. D. Zhu, K. S. Tan, X. Zhang, A. Y. Sun, G. Y. Sun, and J. C.-M. Lee, “Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes,” Journal of Cell Science, vol. 118, no. 16, pp. 3695–3703, 2005. View at Publisher · View at Google Scholar · View at Scopus
  82. M. J. Mihm, F. Yu, P. J. Reiser, and J. A. Bauer, “Effects of peroxynitrite on isolated cardiac trabeculae: selective impact on myofibrillar energetic controllers,” Biochimie, vol. 85, no. 6, pp. 587–596, 2003. View at Publisher · View at Google Scholar · View at Scopus
  83. S. Mochida, H. Kobayashi, Y. Matsuda, Y. Yuda, K. Muramoto, and Y. Nonomura, “Myosin II is involved in transmitter release at synapses formed between rat sympathetic neurons in culture,” Neuron, vol. 13, no. 5, pp. 1131–1142, 1994. View at Publisher · View at Google Scholar · View at Scopus
  84. S. L. Reck-Peterson, D. W. Provance Jr., M. S. Mooseker, and J. A. Mercer, “Class V myosins,” Biochimica et Biophysica Acta, vol. 1496, no. 1, pp. 36–51, 2000. View at Publisher · View at Google Scholar · View at Scopus