Multiple Congenital Anomalies after Assisted Reproductive Technology in Japan (between 2004 and 2009)
Table 3
Proportions of isolated anomalies, syndromes (chromosomal, monogenic, and environmental), and MCAs according to the ICD-10 major organ system categories.
ICD-10
Isolated
Syndromes
MCAs
%
%
%
Q00–Q07
Congenital malformations of the nervous system
63
79.7
2
2.5
14
17.7
Q10–Q18
Congenital malformations of eye, ear, face, and neck
61
70.9
2
2.3
23
26.7
Q20–Q28
Congenital malformations of the circulatory system
399
85.4
30
6.4
38
8.1
Q30–Q34
Congenital malformations of the respiratory system
14
66.7
0
0.0
7
33.3
Q35–Q37
Cleft lip and cleft palate
81
81.8
2
2.0
16
16.2
Q38–Q45
Other congenital malformations of the digestive system
93
73.2
10
7.9
24
18.9
Q50–Q56
Congenital malformations of genital organs
41
71.9
1
1.8
15
26.3
Q60–Q64
Congenital malformations of the urinary system
42
77.8
0
0.0
12
22.2
Q65–Q79
Congenital malformations and deformations of the musculoskeletal system
167
77.0
12
5.5
38
17.5
Q80–Q89
Other congenital malformations
19
30.6
39
62.9
4
6.5
ICD: International Classification of Disease, MCAs: multiple congenital anomalies. The cases with more than one disease name (syndromes and MCAs) were counted in several ICD subgroups according to the disease category number.
