Table of Contents
ISRN Organic Chemistry
Volume 2013, Article ID 453682, 7 pages
Research Article

A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity

1Garware Research Centre, Department of Chemistry, University of Pune, Pune 411007, India
2Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411007, India

Received 14 March 2013; Accepted 3 April 2013

Academic Editors: D. K. Chand, G. Gattuso, and J. C. Menéndez

Copyright © 2013 Vyankat A. Sontakke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines.